ପେଣ୍ଟୋକ୍ସିଫାଇଲିନ

ପେଣ୍ଟୋକ୍ସିଫାଇଲିନ
Clinical data
Pronunciation	/ˌpɛntɒkˈsɪfɪliːn, -ɪn/
Trade names	Pentoxil, Trental, others
Synonyms	Oxpentifylline (former AAN)
AHFS/Drugs.com	monograph
MedlinePlus	a685027
data	US FDA: Pentoxifylline;
Pregnancy; category	AU: B1 ; US: C (Risk not ruled out) ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	10–30%
Metabolism	Liver and via erythrocytes
Elimination half-life	0.4–0.8 hours (1–1.6 hours for active metabolite)
Excretion	Urine (95%), faeces (<4%)
Identifiers
	IUPAC name 3,7-Dimethyl-1-(5-oxohexyl)purine-2,6-dione;
ECHA InfoCard	100.026.704
Chemical and physical data
Formula	C13H18N4O3
Molar mass	୨୭୮.୩୧ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2N(c1ncn(c1C(=O)N2CCCCC(=O)C)C)C;
	InChI InChI=1S/C13H18N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8H,4-7H2,1-3H3 ; Key:BYPFEZZEUUWMEJ-UHFFFAOYSA-N ;
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ପେଣ୍ଟୋକ୍ସିଫାଇଲିନ, ଅକ୍ସପେଣ୍ଟିଫାଇଲିନ ଭାବରେ ମଧ୍ୟ ଜଣାଶୁଣା, ଏକ ଔଷଧ ଯାହା ଚାଲିଲା ବେଳେ ଯନ୍ତ୍ରଣା ଓ ଶିରା ଘାଆ କରୁଥିବା ପ୍ରାନ୍ତୀୟ ଧମନୀ ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୪] ଏହି ଔଷଧ ବ୍ୟବ‌ହାର କଲେ ଲୋକମାନଙ୍କର ଚାଲିବା କ୍ଷମତା ଉନ୍ନତ ହେବାର ପ୍ରମାଣ ମିଳୁଛି ।^[୫] ଯୁକ୍ତରାଜ୍ୟରେ ଏହାର ବ୍ୟବହାର ସୁପାରିଶ କରାଯାଏ ନାହିଁ ।^[୪] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୬]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅଇ, ମୁଣ୍ଡ ବୁଲାଇବା ଏବଂ ବୁକୁଜ୍ୱାଳା ହୋଇପାରେ ।^[୬] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ରକ୍ତସ୍ରାବ ହୋଇପାରେ। ^[୪] ଏହା ଏକ ଜାନ୍ଥିନ ଉତ୍ପାଦିତ ଔଷଧ ଏବଂ ଲାଲ ରକ୍ତ କଣିକାର ନମନୀୟତା ବୃଦ୍ଧି କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ବୋଲି ବିଶ୍ୱାସ କରାଯାଏ ।^[୬]

ପେଣ୍ଟୋକ୍ସିଫାଇଲିନ ୧୯୮୪ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୬] ଏହା ଏକ ଜେନେରିକ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ହୁଏ । ଯୁକ୍ତରାଜ୍ୟରେ ଏହାର ଏକ ମାସ ବ୍ୟବ‌ହାରର ମୂଲ୍ୟ ୧୯ ପାଉଣ୍ଡ ।^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ମୂଲ୍ୟ ୩୬ ଡଲାର ।^[୭]

ଆଧାର

↑ Drugs.com drugs.com international listings for Pentoxifylline Archived 2020-09-25 at the Wayback Machine.. Page accessed Feb 1, 206
↑ "PRODUCT INFORMATION TRENTAL® 400" (PDF). TGA eBusiness Services. sanofi-aventis australia pty limited. 25 March 2010. Archived from the original on 9 August 2017. Retrieved 3 February 2014.
1 2 3 "Trental, Pentoxil (pentoxifylline) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Archived from the original on 4 February 2014. Retrieved 3 February 2014.
1 2 3 4 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 250. ISBN 978-0857114105.
↑ Broderick, Cathryn; Forster, Rachel; Abdel-Hadi, Mohammed; Salhiyyah, Kareem (October 16, 2020). "Pentoxifylline for intermittent claudication". The Cochrane Database of Systematic Reviews. 10: CD005262. doi:10.1002/14651858.CD005262.pub4. ISSN 1469-493X. PMC 8094235. PMID 33063850.
1 2 3 4 "Pentoxifylline Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 18 June 2019. Retrieved 27 October 2021.
↑ "Pentoxifylline Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 20 January 2021. Retrieved 27 October 2021.

[generics-1] Drugs.com drugs.com international listings for Pentoxifylline Archived 2020-09-25 at the Wayback Machine.. Page accessed Feb 1, 206

[TGA-2] "PRODUCT INFORMATION TRENTAL® 400" (PDF). TGA eBusiness Services. sanofi-aventis australia pty limited. 25 March 2010. Archived from the original on 9 August 2017. Retrieved 3 February 2014.

[MSR-3] 1 2 3 "Trental, Pentoxil (pentoxifylline) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Archived from the original on 4 February 2014. Retrieved 3 February 2014.

[BNF81-4] 1 2 3 4 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 250. ISBN 978-0857114105.

[Bro2020-5] Broderick, Cathryn; Forster, Rachel; Abdel-Hadi, Mohammed; Salhiyyah, Kareem (October 16, 2020). "Pentoxifylline for intermittent claudication". The Cochrane Database of Systematic Reviews. 10: CD005262. doi:10.1002/14651858.CD005262.pub4. ISSN 1469-493X. PMC 8094235. PMID 33063850.

[AHFS2021-6] 1 2 3 4 "Pentoxifylline Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 18 June 2019. Retrieved 27 October 2021.

[7] "Pentoxifylline Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 20 January 2021. Retrieved 27 October 2021.

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