ଗ୍ଲାଟିରାମର ଆସେଟେଟ

ଗ୍ଲାଟିରାମର ଆସେଟେଟ
Clinical data
Trade names	Copaxone, Glatopa, Brabio, others
Synonyms	Glatiramer acetate, copolymer 1, Cop-1
AHFS/Drugs.com	monograph
MedlinePlus	a603016
data	US DailyMed: Glatiramer;
Pregnancy; category	AU: B1 ; US: B (No risk in non-human studies) ; ;
Routes of; administration	Subcutaneous injection
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ;
Identifiers
ECHA InfoCard	100.248.824
Chemical and physical data
Formula	C25H45N5O13
Molar mass	୬୨୩.୬୬ g·mol−1
(verify)

ଗ୍ଲାଟିରାମର ଆସେଟେଟ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ କୋପାକ୍ସୋନ, ଏକ ଔଷଧ ଯାହା ମଲ୍ଟିପ୍ଲ ସ୍କ୍ଲେରୋସିସ୍ ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୫] ନିର୍ଦ୍ଦିଷ୍ଟ ଭାବେ ଏହା କ୍ଲିନିକାଲି ଆଇସୋଲେଟେଡ ସିଣ୍ଡ୍ରୋମ୍, ରିଲାପସିଙ୍ଗ-ରେମିଟିଙ୍ଗ୍ ରୋଗ ଏବଂ ସକ୍ରିୟ ଦ୍ୱିତୀୟକ ବା ସେକେଣ୍ଡାରୀ ପ୍ରଗତିଶୀଳ ରୋଗମାନଙ୍କରେ ଦିଆଯାଏ ।^[୧] ଚର୍ମ ତଳେ ଏହା ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ ।^[୫]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଇଞ୍ଜେକ୍ସନ ନେଇଥିବା ସ୍ଥାନରେ ଯନ୍ତ୍ରଣା, ରାସ, ଅଣନିଶ୍ୱାସ ଏବଂ ଛାତିରେ ଯନ୍ତ୍ରଣା ହୁଏ ।^[୧] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଲାଲିମା, ଉଦବେଗ, ଲାଇପୋଟ୍ରୋଫି ଏବଂ ଯକୃତ ସମସ୍ୟା ହୋଇପାରେ ।^[୧] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ କୌଣସି ସ୍ପଷ୍ଟ କ୍ଷତି ହୋଇନଥିବାବେଳେ, ଏପରି ବ୍ୟବହାର ଭଲ ଭାବରେ ଅଧ୍ୟୟନ କରାଯାଇ ନାହିଁ ।^[୬] ଏହା ଗ୍ଲୁଟାମିକ୍ ଏସିଡ୍, ଲାଇସିନ୍, ଆଲାନାଇନ୍ ଏବଂ ଟାଇରୋସିନ୍ ନାମକ ଚାରୋଟି ଆମିନୋ ଏସିଡର ମିଶ୍ରଣ ।^[୭] ଏହା ମାୟେଲିନ ମୌଳିକ ପ୍ରୋଟିନ୍ (MBP) ସହିତ ସମାନ ମନେହୁଏ ଏବଂ ଏହା ବିରୁଦ୍ଧରେ ନିର୍ଦ୍ଦେଶିତ ଆଣ୍ଟିବଡିମାନଙ୍କୁ ନିଷ୍କ୍ରିୟ କରିଥାଏ ବୋଲି ବିଶ୍ୱାସ କରାଯାଏ ।^[୭]

୧୯୯୬ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଗ୍ଲାଟିରାମର ଆସେଟେଟ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୫] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଜରୁରୀ ଔଷଧ ତାଲିକାରେ ଅଛି ।^[୮] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ସୁଦ୍ଧା ୪ ସପ୍ତାହର ଔଷଧ ମୂଲ୍ୟ ୫୧୫ ପାଉଣ୍ଡ ଅଟେ ।^[୯] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୧,୨୦୦ ଡଲାର ଅଟେ ।^[୧୦]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Copaxone- glatiramer acetate injection, solution". DailyMed. 23 July 2020. Archived from the original on 31 October 2021. Retrieved 11 November 2020.
↑ ^୨.୦ ^୨.୧ "Glatopa- glatiramer acetate injection, solution". DailyMed. 31 July 2020. Archived from the original on 17 November 2020. Retrieved 11 November 2020.
↑ "Brabio 20 mg/mL Solution for Injection, Pre-filled Syringe - Summary of Product Characteristics (SmPC)". (emc). Archived from the original on 17 November 2020. Retrieved 11 November 2020.
↑ "Copaxone 20 mg/ml solution for injection in pre-filled syringe - Summary of Product Characteristics (SmPC)". (emc). 29 September 2020. Archived from the original on 12 November 2020. Retrieved 11 November 2020.
↑ ^୫.୦ ^୫.୧ ^୫.୨ "Glatiramer Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 27 November 2021. Retrieved 3 December 2021.
↑ "Glatiramer Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 3 December 2020. Retrieved 3 December 2021.
↑ ^୭.୦ ^୭.୧ Babaesfahani, A; Bajaj, T (January 2021). "Glatiramer". StatPearls. PMID 31082051.
↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
↑ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 898. ISBN 978-0857114105.
↑ "Glatiramer Prices and Glatiramer Coupons - GoodRx". GoodRx. Retrieved 3 December 2021.

[PI2021a-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Copaxone- glatiramer acetate injection, solution". DailyMed. 23 July 2020. Archived from the original on 31 October 2021. Retrieved 11 November 2020.

[Glatopa_FDA_label-2] ୨.୦ ^୨.୧ "Glatopa- glatiramer acetate injection, solution". DailyMed. 31 July 2020. Archived from the original on 17 November 2020. Retrieved 11 November 2020.

[3] "Brabio 20 mg/mL Solution for Injection, Pre-filled Syringe - Summary of Product Characteristics (SmPC)". (emc). Archived from the original on 17 November 2020. Retrieved 11 November 2020.

[4] "Copaxone 20 mg/ml solution for injection in pre-filled syringe - Summary of Product Characteristics (SmPC)". (emc). 29 September 2020. Archived from the original on 12 November 2020. Retrieved 11 November 2020.

[AHFS2021-5] ୫.୦ ^୫.୧ ^୫.୨ "Glatiramer Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 27 November 2021. Retrieved 3 December 2021.

[6] "Glatiramer Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 3 December 2020. Retrieved 3 December 2021.

[Stat2021-7] ୭.୦ ^୭.୧ Babaesfahani, A; Bajaj, T (January 2021). "Glatiramer". StatPearls. PMID 31082051.

[WHO23rd-8] World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.

[BNF81-9] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 898. ISBN 978-0857114105.

[10] "Glatiramer Prices and Glatiramer Coupons - GoodRx". GoodRx. Retrieved 3 December 2021.

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