ଗୁଏଫେନେସିନ

ଗୁଏଫେନେସିନ
Clinical data
Pronunciation	/ɡwaɪˈfɛnɪsɪn/
Trade names	Mucinex, others
Synonyms	Glyceryl guaiacolate
AHFS/Drugs.com	monograph
MedlinePlus	a682494
data	US DailyMed: Guaifenesin;
Pregnancy; category	US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth (tablets, syrup)
Legal status
Legal status	US: OTC / Rx-only;
Pharmacokinetic data
Metabolism	Kidney
Elimination half-life	1–5 hours
Identifiers
	IUPAC name (RS)-3-(2-methoxyphenoxy)propane-1,2-diol;
ECHA InfoCard	100.002.021
Chemical and physical data
Formula	C10H14O4
Molar mass	୧୯୮.୨୨ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O(c1ccccc1OC)CC(O)CO;
	InChI InChI=1S/C10H14O4/c1-13-9-4-2-3-5-10(9)14-7-8(12)6-11/h2-5,8,11-12H,6-7H2,1H3 ; Key:HSRJKNPTNIJEKV-UHFFFAOYSA-N ;
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ଗୁଏଫେନେସିନ, ଏକ ବ୍ୟବସାୟୀକ ନାମ ମୁସିନେକ୍ସ, ^[୨] ଏକ ଔଷଧ ଯାହା ଶ୍ୱାସନଳୀରୁ ଖଙ୍କାର ବାହାର କରିବାରେ ସାହାଯ୍ୟ କରିଥାଏ | ^[୩] ଏହା କାଶକୁ ହ୍ରାସ କରେ କି ନାହିଁ ତାହା ଅସ୍ପଷ୍ଟ। ^[୪] ୬ ବର୍ଷରୁ କମ୍ ପିଲାମାନଙ୍କଠାରେ ବ୍ୟବହାର ସୁପାରିଶ କରାଯାଏ ନାହିଁ | ^[୫] ଏହା ପ୍ରାୟ ଅନ୍ୟ ଔଷଧ ସହିତ ମିଶି ବ୍ୟବହୃତ ହୁଏ | ^[୪] ଏହା ପାଟିରେ ଦିଆଯାଏ | ^[୪]

ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡ ବୁଲାଇବା, ନିଦ୍ରାହୀନତା, ଚର୍ମ ରାସ, ଏବଂ ଅଇ ଲାଗିପାରେ | ^[୨] ଗର୍ଭାବସ୍ଥାରେ ଏହା ସଠିକ୍ ଭାବରେ ଅଧ୍ୟୟନ କରାଯାଇ ନ ଥିବାବେଳେ ଏହା ନିରାପଦ ଥିବା ପରି ମନେହୁଏ | ^[୬] ଶ୍ୱାସନଳୀରେ ଥିବା ବ‌ହଳିଅ ଖଙ୍କାରକୁ ତରଳ କରି ଏହା କାମ କରେ ବୋଲି ବିଶ୍ୱାସ କରାଯାଏ | ^[୩]

ଅନ୍ତତଃ ପକ୍ଷେ ୧୯୩୩ ମସିହା ପରଠାରୁ ^[୭] ଏହା ଚିକିତ୍ସାଳୟରେ ବ୍ୟବହୃତ ହୋଇଆସୁଛି। ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଏବଂ ବିନା ପ୍ରେସକ୍ରିପସନରେ ଉପଲବ୍ଧ | ^[୩] ^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ହୋଲସେଲ ମୂଲ୍ୟ ଡୋଜ ପିଛା ୦.୧୦ ଡଲାରରୁ କମ୍ ଅଟେ। ^[୮] ୨୯୧୭ରେ ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୩୪ତମ ସାଧାରଣ ପ୍ରେସକ୍ରିପସନ ଷଧ ଥିଲା, ଯେଉଁଥିରେ ଦୁଇ ଲକ୍ଷରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ ରହିଥିଲା | ^[୯] ^[୧୦]

ଆଧାର

↑ Aluri JB, Stavchansky S (1993). "Determination of guaifenesin in human plasma by liquid chromatography in the presence of pseudoephedrine". J Pharm Biomed Anal. 11 (9): 803–8. doi:10.1016/0731-7085(93)80072-9. PMID 8218524.
↑ ^୨.୦ ^୨.୧ "Guaifenesin". Drugs.com. Retrieved 2019-03-25.
↑ ^୩.୦ ^୩.୧ ^୩.୨ "Guaifenesin Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 25 March 2019.
↑ ^୪.୦ ^୪.୧ ^୪.୨ "Guaifenesin Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 25 March 2019.
↑ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 295. ISBN 9780857113382.
↑ ^୬.୦ ^୬.୧ Weiner, Carl P.; Rope, Kate (2013). The Complete Guide to Medications During Pregnancy and Breastfeeding: Everything You Need to Know to Make the Best Choices for You and Your Baby (in ଇଂରାଜୀ). St. Martin's Press. p. PT282. ISBN 9781250037206.
↑ Riviere, Jim E.; Papich, Mark G. (2013). Veterinary Pharmacology and Therapeutics (in ଇଂରାଜୀ). John Wiley & Sons. p. 287. ISBN 9781118685907.
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-03-06. Retrieved 3 March 2019.
↑ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
↑ "Guaifenesin - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.

[pmid8218524-1] Aluri JB, Stavchansky S (1993). "Determination of guaifenesin in human plasma by liquid chromatography in the presence of pseudoephedrine". J Pharm Biomed Anal. 11 (9): 803–8. doi:10.1016/0731-7085(93)80072-9. PMID 8218524.

[PPA2019-2] ୨.୦ ^୨.୧ "Guaifenesin". Drugs.com. Retrieved 2019-03-25.

[AHFS2019-3] ୩.୦ ^୩.୧ ^୩.୨ "Guaifenesin Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 25 March 2019.

[autogen1-4] ୪.୦ ^୪.୧ ^୪.୨ "Guaifenesin Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 25 March 2019.

[BNF76-5] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 295. ISBN 9780857113382.

[Wei2013-6] ୬.୦ ^୬.୧ Weiner, Carl P.; Rope, Kate (2013). The Complete Guide to Medications During Pregnancy and Breastfeeding: Everything You Need to Know to Make the Best Choices for You and Your Baby (in ଇଂରାଜୀ). St. Martin's Press. p. PT282. ISBN 9781250037206.

[7] Riviere, Jim E.; Papich, Mark G. (2013). Veterinary Pharmacology and Therapeutics (in ଇଂରାଜୀ). John Wiley & Sons. p. 287. ISBN 9781118685907.

[NADAC2019-8] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-03-06. Retrieved 3 March 2019.

[ref-9] "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.

[ref1-10] "Guaifenesin - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.

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