କ୍ଲୋରଡାଏଜେପୋକ୍ସାଇଡ

କ୍ଲୋରଡାଏଜେପୋକ୍ସାଇଡ
Clinical data
Pronunciation	/ˌklɔːrdaɪ.əzɪˈpɒksaɪd/
Trade names	Librium, others
Synonyms	Methaminodiazepoxide
AHFS/Drugs.com	monograph
MedlinePlus	a682078
Pregnancy; category	US: D (Evidence of risk) ;
Routes of; administration	By mouth, intramuscular
Legal status
Legal status	AU: S4 (Prescription only) ; CA: Schedule IV ; DE: Rx-only/Anlage III ; UK: Class C ; US: Schedule IV ;
Pharmacokinetic data
Metabolism	Liver
Onset of action	Rapid
Elimination half-life	5–30 hours (Active metabolite desmethyldiazepam 36–200 hours: other active metabolites oxazepam)
Duration of action	48 to 72 hr
Excretion	Kidney
Identifiers
	IUPAC name 7-Chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine-4-oxide;
ECHA InfoCard	100.000.337
Chemical and physical data
Formula	C16H14ClN3O
Molar mass	୨୯୯.୭୬ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES ClC1=CC2=C(N=C(NC)C[N+]([O-])=C2C3=CC=CC=C3)C=C1;
	InChI InChI=1S/C16H14ClN3O/c1-18-15-10-20(21)16(11-5-3-2-4-6-11)13-9-12(17)7-8-14(13)19-15/h2-9H,10H2,1H3,(H,18,19) ; Key:ANTSCNMPPGJYLG-UHFFFAOYSA-N ;
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କ୍ଲୋରଡାଏଜେପୋକ୍ସାଇଡ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବାଣିଜ୍ୟିକ ନାମ ଲିବ୍ରିୟମ୍, ଏକ ବେଞ୍ଜୋଡାଏଜେପିନ ଶ୍ରେଣୀର ଏକ ଔଷଧ, ଯାହା ମଦ୍ୟପାନ ପ୍ରତ୍ୟାହାର ଏବଂ ଉଦ୍‌ବେଗ ଅବ୍ୟବସ୍ଥା ଜନିତ ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ | ^[୩] ଏହା ସାଧାରଣତଃ ପାଟିରେ ଦିଆଯାଏ | ^[୪] ୪ ସପ୍ତାହରୁ କମ୍ ସମୟ ପାଇଁ ବ୍ୟବହାର କରିବାକୁ ସୁପାରିଶ କରାଯାଏ | ^[୫] ଏହାର ପ୍ରଭାବ ଦ୍ରୁତ ଗତିରେ ଆରମ୍ଭ ହୁଏ ଏବଂ ତିନି ଦିନ ପର୍ଯ୍ୟନ୍ତ ରହିଥାଏ | ^[୬]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିଦ୍ରା, ଖରାପ ସମନ୍ୱୟ ଏବଂ ଦ୍ୱନ୍ଦ୍ୱ ଅନ୍ତର୍ଭୁକ୍ତ | ^[୩] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଚଳପ୍ରଚଳ ଅସୁବିଧା, ଲିଙ୍ଗୋତ୍ଥାନ ଅସୁବିଧା ଏବଂ ଅସ୍ଥି ମଜ୍ଜା ସମସ୍ୟା ହୋଇପାରେ | ^[୭] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ ଏବଂ ସ୍ତନ୍ୟପାନ ସମୟରେ ଏହା ସୁପାରିଶ କରାଯାଏ ନାହିଁ | ^[୪] ^[୮] ଯକୃତ ଜନିତ ସମସ୍ୟାରେ ଛୋଟ ଛୋଟ ଡୋଜ ସୁପାରିଶ କରାଯାଏ | ^[୮] କ୍ଲୋର୍‌ଡାଏଜେପୋକ୍ସାଇଡ ସ‌ହିତ ଏହାର ମେଟାବୋଲାଇଟ୍ ଥିଲେ ଦୀର୍ଘ ଅଧା ଜୀବନ ରହେ | ^[୪]

୧୮୫୮ ମସିହାରେ କ୍ଲୋର୍‌ଡାଏଜେପୋକ୍ସାଇଡ ପେଟେଣ୍ଟ୍ ହୋଇଥିଲା ଏବଂ ୧୯୬୦ ମସିହାରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା |^[୯] ଏହା ପ୍ରଥମ ବେଞ୍ଜୋଡାଏଜେପିନ୍ ଥିଲା ଏବଂ ସୁଯୋଗ କ୍ରମେ ଆବିଷ୍କୃତ ହୋଇଥିଲା | ^[୧୦] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ଅଟେ | ^[୭] ଯୁକ୍ତରାଜ୍ୟରେ ୧୦ ମିଗ୍ରାର ୧୦୦ ବଟିକା ମୂଲ୍ୟ ୨୦୨୦ ସୁଦ୍ଧା ପ୍ରାୟ ୧୮ ପାଉଣ୍ଡ ଥିଲା ।^[୮] ଯୁକ୍ତରାଷ୍ଟରେ ଏହାର ମୂଲ୍ୟ ୨୯୨୯ ମସିହାରେ ୧୩ ଡଲାର ଥିଲା । ^[୧୧]

ଆଧାର

↑ Ban TA (2006). "The role of serendipity in drug discovery". Dialogues in Clinical Neuroscience. 8 (3): 335–44. PMC 3181823. PMID 17117615.
1 2 Frandsen, Geralyn; Pennington, Sandra Smith (2014). Abrams' Clinical Drug Therapy: Rationales for Nursing Practice (in ଇଂରାଜୀ). Lippincott Williams & Wilkins. p. 1060. ISBN 978-1-60913-711-3. Archived from the original on 2021-08-28. Retrieved 2020-10-30.
1 2 "Chlordiazepoxide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 14 December 2020. Retrieved 29 October 2020.
1 2 3 "Chlordiazepoxide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 14 December 2020. Retrieved 29 October 2020.
↑ "Chlordiazepoxide 10mg Capsules - Summary of Product Characteristics" (in ଇଂରାଜୀ). UK Electronic Medicines Compendium. 19 December 2012. Archived from the original on 23 April 2017. Retrieved 23 April 2017.
↑ Frandsen, Geralyn; Pennington, Sandra Smith (2014). Abrams' Clinical Drug Therapy: Rationales for Nursing Practice (in ଇଂରାଜୀ). Lippincott Williams & Wilkins. p. 1060. ISBN 978-1-60913-711-3. Archived from the original on 2021-08-28. Retrieved 2020-10-30.
1 2 BNF 79 : March 2020. London: Royal Pharmaceutical Society. 2020. p. 352. ISBN 9780857113658.
1 2 3 BNF 79 : March 2020. London: Royal Pharmaceutical Society. 2020. p. 352. ISBN 9780857113658.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 535. ISBN 9783527607495. Archived from the original on 2020-08-01. Retrieved 2020-09-19.
↑ Ban TA (2006). "The role of serendipity in drug discovery". Dialogues in Clinical Neuroscience. 8 (3): 335–44. PMC 3181823. PMID 17117615.
↑ "Chlordiazepoxide Prices and Chlordiazepoxide Coupons". GoodRx (in ଆମେରିକୀୟ ଇଂରାଜୀ). Retrieved 30 October 2020.

[Ban2006-1] Ban TA (2006). "The role of serendipity in drug discovery". Dialogues in Clinical Neuroscience. 8 (3): 335–44. PMC 3181823. PMID 17117615.

[Fran2014-2] 1 2 Frandsen, Geralyn; Pennington, Sandra Smith (2014). Abrams' Clinical Drug Therapy: Rationales for Nursing Practice (in ଇଂରାଜୀ). Lippincott Williams & Wilkins. p. 1060. ISBN 978-1-60913-711-3. Archived from the original on 2021-08-28. Retrieved 2020-10-30.

[AHFS2020-3] 1 2 "Chlordiazepoxide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 14 December 2020. Retrieved 29 October 2020.

[autogen4-4] 1 2 3 "Chlordiazepoxide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 14 December 2020. Retrieved 29 October 2020.

[UKlabelGeneric-5] "Chlordiazepoxide 10mg Capsules - Summary of Product Characteristics" (in ଇଂରାଜୀ). UK Electronic Medicines Compendium. 19 December 2012. Archived from the original on 23 April 2017. Retrieved 23 April 2017.

[autogen5-6] Frandsen, Geralyn; Pennington, Sandra Smith (2014). Abrams' Clinical Drug Therapy: Rationales for Nursing Practice (in ଇଂରାଜୀ). Lippincott Williams & Wilkins. p. 1060. ISBN 978-1-60913-711-3. Archived from the original on 2021-08-28. Retrieved 2020-10-30.

[BNF79-7] 1 2 BNF 79 : March 2020. London: Royal Pharmaceutical Society. 2020. p. 352. ISBN 9780857113658.

[autogen1-8] 1 2 3 BNF 79 : March 2020. London: Royal Pharmaceutical Society. 2020. p. 352. ISBN 9780857113658.

[Fis2006-9] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 535. ISBN 9783527607495. Archived from the original on 2020-08-01. Retrieved 2020-09-19.

[autogen3-10] Ban TA (2006). "The role of serendipity in drug discovery". Dialogues in Clinical Neuroscience. 8 (3): 335–44. PMC 3181823. PMID 17117615.

[GX2020-11] "Chlordiazepoxide Prices and Chlordiazepoxide Coupons". GoodRx (in ଆମେରିକୀୟ ଇଂରାଜୀ). Retrieved 30 October 2020.

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