ଗାଲାଣ୍ଟାମାଇନ

ଗାଲାଣ୍ଟାମାଇନ
Clinical data
Trade names	Razadyne, Reminyl, GalantaMind, others
Synonyms	Galantamine hydrobromide
AHFS/Drugs.com	monograph
MedlinePlus	a699058
data	US DailyMed: Razadyne;
Pregnancy; category	AU: B1 ; US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth
Legal status
Legal status	EU: Rx-only ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	80–100%
Protein binding	18%
Metabolism	Liver partially CYP450:CYP2D6/3A4 substrate
Elimination half-life	7 hours
Excretion	Kidney (95%, of which 32% unchanged), fecal (5%)
Identifiers
	IUPAC name (4aS,6R,8aS)-5,6,9,10,11,12-Hexahydro-3-methoxy-11-methyl-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol;
ECHA InfoCard	100.118.289
Chemical and physical data
Formula	C17H21NO3
Molar mass	୨୮୭.୩୬ g·mol−1
3D model (JSmol)	Interactive image;
Melting point	126.5 °C (259.7 °F)
	SMILES O(c2c1O[C@H]4C[C@@H](O)/C=C\[C@@]43c1c(cc2)CN(C)CC3)C;
	InChI InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1 ; Key:ASUTZQLVASHGKV-JDFRZJQESA-N ;
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ଗାଲାଣ୍ଟାମାଇନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ରାଜାଡାଇନ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ସାମାନ୍ୟରୁ ମଧ୍ୟମ ଧରଣରଆଲଜିମର ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୩]^[୪] ଡିମେନ୍ସିଆ ଉଇଥ ଲୁଇ ବଡିଜ ରୋଗରେ କୌଣସି ଚିକିତ୍ସା ଫଳପ୍ରଦ ନ ହେଲେ ଏହା ବ୍ୟବହୃତ ହୋଇପାରେ ।^[୫] ଜ୍ଞାନାତ୍ମକ ଦୁର୍ବଳତା ଥିଲେ ଏହି ଔଷଧଦ୍ୱାରା ଫଳାଫଳ ଖରାପ ହୋଇପାରେ। ।^[୩] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅନିୟମିତ ହୃତ୍ ସ୍ପନ୍ଦନ, ଉଚ୍ଚ ରକ୍ତଚାପ ଏବଂ କମ୍ପନ ହୋଇପାରେ ।^[୫] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଖାଦ୍ୟନଳୀ ରକ୍ତସ୍ରାବ, ୟୁରିନାରି ରିଟେନସନ, ବାତ ଏବଂ ଷ୍ଟିଭେନ୍ସ-ଜନସନ ସିଣ୍ଡ୍ରୋମ ହୋଇପାରେ ।^[୩] ଏହା ଏକ ଆଣ୍ଟିକୋଲିନ‌ଇଷ୍ଟେରେଜ ଇନହିବିଟର ଯାହା ମସ୍ତିଷ୍କରେ ଥିବା କୋଲିନରଜିକ୍ ସିନାପ୍ସରେ ଆସେଟିଲକୋଲିନ୍ ବୃଦ୍ଧି କରେଇଥାଏ ।^[୫] ^[୩]

୨୦୦୧ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଗାଲାଣ୍ଟାମାଇନ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୩] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୫] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ସୁଦ୍ଧା ୪ ସପ୍ତାହର ଔଷଧ ପାଇଁ ୮୦ ପାଉଣ୍ଡ ପର୍ଯ୍ୟନ୍ତ ଖର୍ଚ୍ଚ ହୁଏ ।^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ଔଷଧ ମୂଲ୍ୟ ପ୍ରାୟ୬୬ ଡଲାର ଅଟେ ।^[୬]

ଆଧାର[ସମ୍ପାଦନା]

↑ ^୧.୦ ^୧.୧ "Galantamine Use During Pregnancy". Drugs.com. 18 February 2019. Archived from the original on 25 February 2020. Retrieved 24 February 2020.
↑ "Archive copy" (PDF). Archived (PDF) from the original on 2021-10-31. Retrieved 2021-09-26.{{cite web}}: CS1 maint: archived copy as title (link)
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ "Galantamine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 19 October 2021. Retrieved 2 December 2021.
↑ Birks J (January 2006). "Cholinesterase inhibitors for Alzheimer's disease". The Cochrane Database of Systematic Reviews (1): CD005593. doi:10.1002/14651858.CD005593. PMID 16437532.
↑ ^୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 318. ISBN 978-0857114105.
↑ "Galantamine Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 19 October 2021. Retrieved 2 December 2021.

[Drugs.com_pregnancy-1] ୧.୦ ^୧.୧ "Galantamine Use During Pregnancy". Drugs.com. 18 February 2019. Archived from the original on 25 February 2020. Retrieved 24 February 2020.

[2] "Archive copy" (PDF). Archived (PDF) from the original on 2021-10-31. Retrieved 2021-09-26.{{cite web}}: CS1 maint: archived copy as title (link)

[AHFS2021-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ "Galantamine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 19 October 2021. Retrieved 2 December 2021.

[Birk2006-4] Birks J (January 2006). "Cholinesterase inhibitors for Alzheimer's disease". The Cochrane Database of Systematic Reviews (1): CD005593. doi:10.1002/14651858.CD005593. PMID 16437532.

[BNF81-5] ୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 318. ISBN 978-0857114105.

[6] "Galantamine Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 19 October 2021. Retrieved 2 December 2021.

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