ଭେନେଟୋକ୍ଲାକ୍ସ

ଭେନେଟୋକ୍ଲାକ୍ସ
Clinical data
Trade names	Venclexta, Venclyxto
Synonyms	GDC-0199, ABT-199, RG-7601
AHFS/Drugs.com	monograph
MedlinePlus	a616028
data	EU EMA: yes; US DailyMed: Venetoclax;
Pregnancy; category	AU: C ; US: N (Not classified yet) ; ;
Routes of; administration	By mouth (tablets)
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Pharmacokinetic data
Protein binding	>99.9%
Metabolism	Liver (CYP3A4, CYP3A5)
Elimination half-life	~26 hours
Excretion	Feces (>99.9%; 20.8% as unchanged venetoclax)
Identifiers
	IUPAC name 4-(4-{[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl}-1-piperazinyl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide;
ECHA InfoCard	100.254.611
Chemical and physical data
Formula	C45H50ClN7O7S
Molar mass	୮୬୮.୪୫ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1(CCC(=C(C1)c2ccc(cc2)Cl)CN3CCN(CC3)c4ccc(c(c4)Oc5cc6cc[nH]c6nc5)C(=O)NS(=O)(=O)c7ccc(c(c7)[N+](=O)[O-])NCC8CCOCC8)C;
	InChI InChI=1S/C45H50ClN7O7S/c1-45(2)15-11-33(39(26-45)31-3-5-34(46)6-4-31)29-51-17-19-52(20-18-51)35-7-9-38(42(24-35)60-36-23-32-12-16-47-43(32)49-28-36)44(54)50-61(57,58)37-8-10-40(41(25-37)53(55)56)48-27-30-13-21-59-22-14-30/h3-10,12,16,23-25,28,30,48H,11,13-15,17-22,26-27,29H2,1-2H3,(H,47,49)(H,50,54) COPY; Key:LQBVNQSMGBZMKD-UHFFFAOYSA-N;

ଭେନେଟୋକ୍ଲାକ୍ସ, ବେପାର ନାମ ଭେନେକ୍ଲେକ୍ସଟା ଓ ଭେଙ୍କ୍ଲିକ୍ସଟୋ, ହେଉଛି ଏକ ଔଷଧ ଯାହା କ୍ରୋନିକ୍ ଲିମ୍ଫୋସାଇଟିକ ଲ୍ୟୁକେମିଆ (CLL), ସ୍ମଲ ଲିମ୍ଫୋସାଇଟିକ ଲିମ୍ଫୋମା (SLL) କିମ୍ବାଆକ୍ୟୁଟ ମାଇଲୋଏଡ୍ ଲ୍ୟୁକେମିଆ (AML) ରୋଗମାନଙ୍କର ଚିକିତ୍ସା ପାଇଁ ହୁଏ ।^[୪]^[୨] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୨] ଏହାକୁ ଏକ‌କ ଭାବରେ କିମ୍ବା ଅନ୍ୟାନ୍ୟ ଔଷଧ ସହିତ ମିଶ୍ରିତ ଭାବରେ ବ୍ୟବହୃତ ହୋଇପାରେ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ସ୍ୱଳ୍ପ ଶ୍ୱେତ ରକ୍ତ କଣିକା, ସ୍ୱଳ୍ପ ଲୋହିତ ରକ୍ତ କଣିକା, ଉଚ୍ଚ ରକ୍ତ ପୋଟାସିୟମ୍ ସ୍ତର , ତରଳ ଝାଡ଼ା, ଅଇ, ଶ୍ୱାସକ୍ରିୟା ସଂକ୍ରମଣ ଏବଂ ଥକାପଣ ହୋଇପାରେ ।^[୨] ଅନ୍ୟ ଗୁରୁତର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ସେପ୍ସିସ୍, କମ୍ ପୋଟାସିୟମ୍, ଟ୍ୟୁମର୍ ଲାଇସିସ୍ ସିଣ୍ଡ୍ରୋମ ଏବଂ ରକ୍ତସ୍ରାବ ହୋଇପାରେ ।^[୨] ^[୫] ଏହା ସେଣ୍ଟ ଜନ୍ ୱର୍ଟ ସହିତ ପ୍ରତିକ୍ରିୟା କରିଥାଏ ।^[୨] ଏହା ବିସିଏଲ-୨ (Bcl-2) ନାମକ ଏକ ପ୍ରୋଟିନ୍ ସଂଲଗ୍ନ ହୋଇ ତାହାର କାର୍ଯ୍ୟକଳାପକୁ ଅବରୋଧ କରେ ଯାହାଦ୍ୱାରା କର୍କଟ କୋଷଗୁଡ଼ିକର ମୃତ୍ୟୁ ହୋଇଥାଏ ।^[୨]

୨୦୧୬ ମସିହାରେ ୟୁରୋପରେ ଏବଂ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ପାଇଁ ଭେନେଟୋକ୍ଲାକ୍ସ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୨] ^[୫] ^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୧୦୦ମିଗ୍ରା ବିଶିଷ୍ଟ ୧୧୨ଟି ବଟିକାର ମୂଲ୍ୟ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରାୟ ୧୨,୬୦୦ ଡଲାର ଥିଲା ।^[୭]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Venetoclax (Venclexta) Use During Pregnancy". Drugs.com. 29 May 2019. Archived from the original on 19 January 2021. Retrieved 25 April 2020.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ ^୨.୭ ^୨.୮ "Venclyxto EPAR". European Medicines Agency (EMA). Archived from the original on 16 April 2020. Retrieved 25 April 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
↑ "Venclyxto 10 mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 21 April 2020. Archived from the original on 26 April 2021. Retrieved 25 April 2020.
↑ ^୪.୦ ^୪.୧ ^୪.୨ "Venclexta- venetoclax kit Venclexta- venetoclax tablet, film coated". DailyMed. 12 November 2019. Archived from the original on 15 June 2020. Retrieved 25 April 2020.
↑ ^୫.୦ ^୫.୧ "Venetoclax Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 31 May 2021. Retrieved 13 September 2021.
↑ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1066. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ "Venclexta Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 16 January 2021. Retrieved 13 September 2021.

[Drugs.com_pregnancy-1] ୧.୦ ^୧.୧ "Venetoclax (Venclexta) Use During Pregnancy". Drugs.com. 29 May 2019. Archived from the original on 19 January 2021. Retrieved 25 April 2020.

[EPAR2021-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ ^୨.୭ ^୨.୮ "Venclyxto EPAR". European Medicines Agency (EMA). Archived from the original on 16 April 2020. Retrieved 25 April 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[3] "Venclyxto 10 mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 21 April 2020. Archived from the original on 26 April 2021. Retrieved 25 April 2020.

[FDA2021-4] ୪.୦ ^୪.୧ ^୪.୨ "Venclexta- venetoclax kit Venclexta- venetoclax tablet, film coated". DailyMed. 12 November 2019. Archived from the original on 15 June 2020. Retrieved 25 April 2020.

[AHFS2021-5] ୫.୦ ^୫.୧ "Venetoclax Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 31 May 2021. Retrieved 13 September 2021.

[BNF80-6] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1066. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[7] "Venclexta Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 16 January 2021. Retrieved 13 September 2021.

[୧]

[୩]

[୪]

[୨]

[୫]

[୬]

[୭]