ନେଫାଜୋଡୋନ

ନେଫାଜୋଡୋନ
Clinical data
Trade names	Serzone, Dutonin, Nefadar, others
Synonyms	BMY-13754-1; MJ-13754-1
AHFS/Drugs.com	monograph
MedlinePlus	a695005
Pregnancy; category	C;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	20% (variable)
Protein binding	99% (loosely)
Metabolism	Liver (CYP3A4, CYP2D6)
Metabolites	• Hydroxynefazodone; • mCPP; • p-Hydroxynefazodone; • Triazoledione
Elimination half-life	• Nefazodone: 2–4 hours; • Hydroxynefazodone: 1.5–4 hours; • Triazoledione: 18 hours; • mCPP: 4–8 hours
Excretion	Urine: 55%; Feces: 20–30%
Identifiers
	IUPAC name 1-(3-[4-(3-chlorophenyl)piperazin-1-yl]propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)-one;
Chemical and physical data
Formula	C25H32ClN5O2
Molar mass	୪୭୦.୦୧ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc4cccc(N3CCN(CCCN1/N=C(\N(C1=O)CCOc2ccccc2)CC)CC3)c4;
	InChI InChI=1S/C25H32ClN5O2/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22/h3-6,8-11,20H,2,7,12-19H2,1H3 ; Key:VRBKIVRKKCLPHA-UHFFFAOYSA-N ;
(verify)

ନେଫାଜୋଡୋନ ହେଉଛି ଏକ ଔଷଧ ଯାହା ମୁଖ୍ୟତଃ major ପ୍ରମୁଖ ଉଦାସୀନ ବେମାରୀ ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୩] ଏହା ବ୍ୟବ‌ହାର ହେଉଥିବା ଅନ୍ୟାନ୍ୟ ରୋଗମାନଙ୍କର ନାମ ଆକ୍ରମଣାତ୍ମକ ଆଚରଣ ଏବଂ ପ୍ୟାନିକ ଡିଜଅର୍ଡ଼ର ଅନ୍ତର୍ଭୁକ୍ତ ।^[୪] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୩] ପ୍ୟାନିକ ଡିଜଅର୍ଡ଼ର

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିଦ୍ରାଳୁ ଭାବ, ଶୁଖିଲା ପାଟି, ଅଇ, କୋଷ୍ଠକାଠିନ୍ୟ, ଅସ୍ପଷ୍ଟ ଦୃଷ୍ଟିଶକ୍ତି ଏବଂ ଦ୍ୱନ୍ଦ୍ୱ ହୋଇପାରେ ।^[୩] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଯକୃତ ସମସ୍ୟା, ଆତ୍ମହତ୍ୟା, ବାଇପୋଲାର ଡିଜଅର୍ଡ଼ର, ବାତ ଏବଂ ପ୍ରିଆପିଜ୍ମ ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ ।^[୩] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ ।^[୫] ଏହାର କାର୍ଯ୍ୟ ଶୈଳୀ ସମ୍ପୂର୍ଣ୍ଣ ରୂପେ ସ୍ପଷ୍ଟ ନୁହେଁ କିନ୍ତୁ ମସ୍ତିଷ୍କ ମଧ୍ୟରେ ୫-ଏଚଟି (5-HT) ଏବଂ ନର୍‌ଏପିନେଫ୍ରିନ ଉପରେ ପ୍ରଭାବ ପକାଇପାରେ ।^[୧]

ନେଫାଜୋଡୋନ ୧୯୮୨ ମସିହାର ପେଟେଣ୍ଟ କରାଯାଇଥିଲା ଏବଂ ୧୯୮୮ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୪] ^[୬] ଏହା ଏକ ଜେନେରିକ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ । ^[୩] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୨୧ ସୁଦ୍ଧା ମାସକୁ ଏହା ପିଛା ପ୍ରାୟ ୨୬୦ ଡଲାର ଖର୍ଚ୍ଚ ହୋଇଥାଏ ।^[୭] ଏହା ଆଉ ସାଧାରଣତଃ ବ୍ୟବହୃତ ହେଉନାହିଁ ।^[୪]

ଆଧର

1 2 3 4 5 6 7 8 9 10 Alan F. Schatzberg, M.D.; Charles B. Nemeroff, M.D., Ph.D. (2017). The American Psychiatric Association Publishing Textbook of Psychopharmacology, Fifth Edition. American Psychiatric Pub. pp. 460–. ISBN 978-1-58562-523-9.{{cite book}}: CS1 maint: multiple names: authors list (link)
1 2 Gian Maria Pacifici; Olavi Pelkonen (24 May 2001). Interindividual Variability in Human Drug Metabolism. CRC Press. pp. 103–. ISBN 978-0-7484-0864-1. Archived from the original on 6 August 2020. Retrieved 20 October 2021.
1 2 3 4 5 "Nefazodone Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 27 February 2021. Retrieved 12 November 2021.
1 2 3 "Nefazodone". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 2021-05-06. Retrieved 2021-11-12.
↑ "Nefazodone (Serzone) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 November 2020. Retrieved 12 November 2021.
↑ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 857–. ISBN 978-1-4757-2085-3. Archived from the original on 6 August 2020. Retrieved 20 October 2021.
↑ "Nefazodone Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 7 March 2021. Retrieved 12 November 2021.

[Sch2017-1] 1 2 3 4 5 6 7 8 9 10 Alan F. Schatzberg, M.D.; Charles B. Nemeroff, M.D., Ph.D. (2017). The American Psychiatric Association Publishing Textbook of Psychopharmacology, Fifth Edition. American Psychiatric Pub. pp. 460–. ISBN 978-1-58562-523-9.{{cite book}}: CS1 maint: multiple names: authors list (link)

[PacificiPelkonen2001-2] 1 2 Gian Maria Pacifici; Olavi Pelkonen (24 May 2001). Interindividual Variability in Human Drug Metabolism. CRC Press. pp. 103–. ISBN 978-0-7484-0864-1. Archived from the original on 6 August 2020. Retrieved 20 October 2021.

[AHFS2021-3] 1 2 3 4 5 "Nefazodone Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 27 February 2021. Retrieved 12 November 2021.

[Liv2012-4] 1 2 3 "Nefazodone". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 2021-05-06. Retrieved 2021-11-12.

[5] "Nefazodone (Serzone) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 November 2020. Retrieved 12 November 2021.

[Elks2014-6] J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 857–. ISBN 978-1-4757-2085-3. Archived from the original on 6 August 2020. Retrieved 20 October 2021.

[7] "Nefazodone Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 7 March 2021. Retrieved 12 November 2021.

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