ମିନୋକ୍ସିଡିଲ

ମିନୋକ୍ସିଡିଲ
Clinical data
Trade names	Rogaine, others
AHFS/Drugs.com	Systemic: monograph; Topical: monograph
MedlinePlus	a682608
data	US DailyMed: Minoxidil;
Pregnancy; category	AU: C ; US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth, topical
Legal status
Legal status	UK: Pharmacy medicines (for topical use, otherwise POM. Cannot be prescribed on the NHS); US: OTC Rx only for by mouth form;
Pharmacokinetic data
Metabolism	Primarily liver
Elimination half-life	4 hours
Excretion	Kidney
Identifiers
	IUPAC name 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide; 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide; 2,4-pyrimidinediamine,6-(1-piperidinyl)-, 3-oxide;
ECHA InfoCard	100.048.959
Chemical and physical data
Formula	C9H15N5O
Molar mass	୨୦୯.୨୫ g·mol−1
3D model (JSmol)	Interactive image;
Melting point	248 °C (478 °F)
Solubility in water	<1 mg/mL (20 °C)
	SMILES Nc1cc(nc(N)[n+]1[O-])N2CCCCC2;
	InChI InChI=1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6H,1-5,10H2,(H2,11,12) ; Key:ZFMITUMMTDLWHR-UHFFFAOYSA-N ;
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ମିନୋକ୍ସିଡିଲ ଏକ ଔଷଧ ଯାହା ଉଚ୍ଚ ରକ୍ତଚାପ ଏବଂ ପୁରୁଷଙ୍କ ନମୁନା କେଶହାନୀରେ ଦିଆଯାଏ ।^[୫] ^[୬] ଉଚ୍ଚ ରକ୍ତଚାପ ପାଇଁ, ଏହା କେବଳ ପରାମର୍ଶ ଦିଆଯାଏ ଯେତେବେଳେ ରୋଗ ଗୁରୁତର ଥାଏ ଏବଂ ଏକ ଡାଇୟୁରେଟିକସ ଏବଂ ବିଟାବ୍ଲର ଚିକିତ୍ସାରେ ନିୟନ୍ତ୍ରିତ ହୁଏନି | ^[୭] ପୁରୁଷ-ନମୁନା କେଶହାନୀ ପାଇଁ ଏହା ଉଭୟ ପୁରୁଷ ଓ ମହିଳାମାନଙ୍କ କ୍ଷେତ୍ରରେ ପ୍ରଭାବଶାଳୀ | ^[୮] ଉଚ୍ଚ ରକ୍ତଚାପ ପାଇଁ ଏହା ପାଟିରେ ଦିଆଯାଉଥିବାବେଳେ କେଶହାନୀ ପାଇଁ ଏହା ଚର୍ମରେ ପ୍ରୟୋଗ କରାଯାଏ | ^[୯] ^[୮]

ପାଟିଦ୍ୱାରା ନିଆଯାଉଥିବା ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଫୁଲା, ପେରିକାର୍ଡିଆଲ ସ୍ରାବ, କେଶ ବୃଦ୍ଧି, ଏବଂ ବାନ୍ତି ଲାଗେ | ^[୫] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ସ୍ୱଳ୍ପ ଶ୍ୱେତ ରକ୍ତ କଣିକା , ଷ୍ଟିଭେନ୍ସ-ଜନସନ ସିଣ୍ଡ୍ରୋମ ଏବଂ ଆଞ୍ଜାଇନା ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ |^[୭] ଚର୍ମରେ ପ୍ରୟୋଗ କରାଯାଉଥିବା ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଏବଂ ଗଲୁ ଓ ସ୍ଥାନୀୟ ଉତ୍ତେଜନା ହୋଇପାରେ | ^[୬] ଗର୍ଭାବସ୍ଥାରେ ଏବଂ ସ୍ତନ୍ୟପାନରେ ନିରାପତ୍ତା ଅସ୍ପଷ୍ଟ ଏବଂ ଏହା ବ୍ୟବହାର କରାଯାଏ ନାହିଁ ।^[୧୦] ଉଚ୍ଚ ରକ୍ତଚାପର ଔଷଧ ଭାବରେ ଏହା ରକ୍ତନଳୀମାନଙ୍କୁ ବିସ୍ତାର କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୧୧] କେଶହାନୀରେ ଏହା କିପରି କାମ କରେ ତାହା ସମ୍ପୂର୍ଣ୍ଣ ସ୍ପଷ୍ଟ ନୁହେଁ | ^[୮]

୧୯୭୯ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସାରେ ବ୍ୟବହାର ପାଇଁ ମିନୋକ୍ସିଡିଲ୍ ଅନୁମୋଦିତ ହୋଇଥିଲା। ^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହା ଟ୍ୟାବଲେଟ ନିମନ୍ତେ ପ୍ରେସକ୍ରିପନରେ ଏବଂ ଚର୍ମରେ ବ୍ୟବହାର ପାଇଁ ସାଧାରଣ ଔଷଧ ଭାବରେ ମିଳେ ।^[୧୨] ^[୭] ^[୬] ଦିନକୁ ୫ ମିଗ୍ରା ଡୋଜରେ ଏହା ଏନଏଚଏସକୁ ୨୦୨୦ ସୁଦ୍ଧା ମାସକୁ ପ୍ରାୟ ୯ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ କରିଥାଏ |

ଆଧାର[ସମ୍ପାଦନା]

↑ Benowitz, Neal L. (2020). "11. Antihypertensive agents". In Katzung, Bertram G.; Trevor, Anthony J. (eds.). Basic and Clinical Pharmacology (in ଇଂରାଜୀ) (15th ed.). New York: McGraw-Hill. p. 183-186. ISBN 978-1-260-45231-0. Archived from the original on 2021-10-10. Retrieved 2021-12-05.
↑ product, sigma. "M4145 Sigma ≥99% (TLC)". sigmaaldrich.com. sigma. Archived from the original on 2 October 2016. Retrieved 29 September 2016.
↑ cayman chemical, company. "safety data sheet" (PDF). caymanchem.com. cayman chemical company. Archived (PDF) from the original on 1 October 2016. Retrieved 29 September 2016.
↑ archives, dailymed. "loniten- minoxidil tablet". dailymed.nlm.nih.gov. dailymed. Archived from the original on 16 August 2016. Retrieved 29 September 2016.
↑ ^୫.୦ ^୫.୧ ^୫.୨ "Minoxidil Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). AHFS. Archived from the original on 16 November 2018. Retrieved 5 October 2020.
↑ ^୬.୦ ^୬.୧ ^୬.୨ "Minoxidil topical Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). AHFS. Archived from the original on 29 October 2020. Retrieved 5 October 2020.
↑ ^୭.୦ ^୭.୧ ^୭.୨ BNF 79. London: Pharmaceutical Press. March 2020. p. 186. ISBN 978-0857113658.
↑ ^୮.୦ ^୮.୧ ^୮.୨ "Minoxidil topical Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). AHFS. Archived from the original on 29 October 2020. Retrieved 5 October 2020.
↑ BNF 79. London: Pharmaceutical Press. March 2020. p. 186. ISBN 978-0857113658.
↑ "Minoxidil (Loniten) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 30 November 2020. Retrieved 5 October 2020.
↑ Benowitz, Neal L. (2020). "11. Antihypertensive agents". In Katzung, Bertram G.; Trevor, Anthony J. (eds.). Basic and Clinical Pharmacology (in ଇଂରାଜୀ) (15th ed.). New York: McGraw-Hill. p. 183-186. ISBN 978-1-260-45231-0. Archived from the original on 2021-10-10. Retrieved 2021-12-05.
↑ "Minoxidil Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). AHFS. Archived from the original on 16 November 2018. Retrieved 5 October 2020.

[Katzung2021-1] Benowitz, Neal L. (2020). "11. Antihypertensive agents". In Katzung, Bertram G.; Trevor, Anthony J. (eds.). Basic and Clinical Pharmacology (in ଇଂରାଜୀ) (15th ed.). New York: McGraw-Hill. p. 183-186. ISBN 978-1-260-45231-0. Archived from the original on 2021-10-10. Retrieved 2021-12-05.

[2] roduct, sigma. "M4145 Sigma ≥99% (TLC)". sigmaaldrich.com. sigma. Archived from the original on 2 October 2016. Retrieved 29 September 2016.

[3] yman chemical, company. "safety data sheet" (PDF). caymanchem.com. cayman chemical company. Archived (PDF) from the original on 1 October 2016. Retrieved 29 September 2016.

[4] rchives, dailymed. "loniten- minoxidil tablet". dailymed.nlm.nih.gov. dailymed. Archived from the original on 16 August 2016. Retrieved 29 September 2016.

[AHFS2020Oral-5] ୫.୦ ^୫.୧ ^୫.୨ "Minoxidil Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). AHFS. Archived from the original on 16 November 2018. Retrieved 5 October 2020.

[AHFS2020Top-6] ୬.୦ ^୬.୧ ^୬.୨ "Minoxidil topical Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). AHFS. Archived from the original on 29 October 2020. Retrieved 5 October 2020.

[BNF79-7] ୭.୦ ^୭.୧ ^୭.୨ BNF 79. London: Pharmaceutical Press. March 2020. p. 186. ISBN 978-0857113658.

[autogen3-8] ୮.୦ ^୮.୧ ^୮.୨ "Minoxidil topical Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). AHFS. Archived from the original on 29 October 2020. Retrieved 5 October 2020.

[autogen1-9] BNF 79. London: Pharmaceutical Press. March 2020. p. 186. ISBN 978-0857113658.

[Preg20202-10] "Minoxidil (Loniten) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 30 November 2020. Retrieved 5 October 2020.

[autogen5-11] Benowitz, Neal L. (2020). "11. Antihypertensive agents". In Katzung, Bertram G.; Trevor, Anthony J. (eds.). Basic and Clinical Pharmacology (in ଇଂରାଜୀ) (15th ed.). New York: McGraw-Hill. p. 183-186. ISBN 978-1-260-45231-0. Archived from the original on 2021-10-10. Retrieved 2021-12-05.

[autogen2-12] "Minoxidil Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). AHFS. Archived from the original on 16 November 2018. Retrieved 5 October 2020.

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