ଫୋଷ୍ଟାମାଟିନିବ

ଫୋଷ୍ଟାମାଟିନିବ
Clinical data
Trade names	Tavalisse, Tavlesse
Synonyms	Fostamatinib disodium hexahydrate, tamatinib fosdium, R-788, NSC-745942, R-935788
AHFS/Drugs.com	monograph
MedlinePlus	a618025
data	EU EMA: yes; US DailyMed: Fostamatinib;
Pregnancy; category	US: N (Not classified yet) ; Not recommended;
Routes of; administration	By mouth
Legal status
Legal status	US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	55% (tamatinib metabolite)
Protein binding	98% (tamatinib metabolite)
Metabolism	Gut (ALP to tamatinib); Liver (tamatinib metabolite by CYP3A4, UGT1A9)
Elimination half-life	15 hours
Excretion	faecal (80%), urine (20%)
Identifiers
	IUPAC name [6-({5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl}amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate;
ECHA InfoCard	100.125.771
Chemical and physical data
Formula	C23H26FN6O9P
Molar mass	୫୮୦.୪୭ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Fc1cnc(nc1Nc2nc3N(C(=O)C(Oc3cc2)(C)C)COP(=O)(O)O)Nc4cc(OC)c(OC)c(OC)c4;
	InChI InChI=1S/C23H26FN6O9P/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29) ;

ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Fostamatinib

ଫୋଷ୍ଟାମାଟିନିବ (ଇଂରାଜୀ ଭାଷାରେ Fostamatinib), ଟାଭାଲିସ୍ ଏବଂ ଟାଭଲେସ୍ ଏହାର ବେପାର ନାମ, ହେଉଛି ଏକ ଔଷଧ ଯାହା କ୍ରନିକ ଇମ୍ୟୁନ ଥ୍ରୋମ୍ବୋସାଇଟୋପେନିଆ (ITP)ର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୨] ଅନ୍ୟାନ୍ୟ ଔଷଧ କାମ କରୁନଥିବା କ୍ଷେତ୍ରରେ ଏହା ବ୍ୟବହୃତ ହୁଏ ।^[୨] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତରଳ ଝାଡ଼ା, ଉଚ୍ଚ ରକ୍ତଚାପ, ଅଇ, ଶ୍ୱାସନଳୀ ସଂକ୍ରମଣ, ମୁଣ୍ଡ ବୁଲାଇବା, ଯକୃତ ସମସ୍ୟା, ରାସ, ପେଟ ଯନ୍ତ୍ରଣା, ଥକାପଣ, ଛାତି ଯନ୍ତ୍ରଣା ଏବଂ ସ୍ୱଳ୍ପ ଶ୍ୱେତ ରକ୍ତକଣିକା ହୋଇପାରେ ।^[୨] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ । ^[୨] ଏହା ଏକ ଟାଇରୋସିନ କାଇନେଜ ଇନହିବିଟର ଯାହା ଏନଜାଇମ ସ୍ପ୍ଲିନ ଟାଇରୋସିନ କାଇନେଜକୁ (SYK) ଅବରୋଧ କରିଥାଏ । ଏହା ପ୍ଲାଟେଲେଟର ପ୍ରତିରକ୍ଷା ପ୍ରଣାଳୀର ବିନାଶକୁ ହ୍ରାସ କରିଥାଏ ।^[୩]

୨୦୧୮ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏବଂ ୨୦୨୦ରେ ୟୁରୋପରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଫୋଷ୍ଟାମାଟିନିବ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୪] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ମସିହାରେ ଥରକୁ ୧୫୦ ମିଗ୍ରା, ଦିନକୁ ଦୁଇଥର ଭାବରେ ଦେଲେ ମାସକୁ ପ୍ରାୟ ୪,୬୦୦ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହେଉଥିଲା । ^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୁଲ୍ୟ ପ୍ରାୟ ୧୩,୦୦୦ ଡଲାର ଅଟେ ।^[୬]

ଆଧାର

↑ "Fostamatinib (Tavalisse) Use During Pregnancy". Drugs.com. 22 October 2018. Archived from the original on 26 March 2020. Retrieved 5 May 2020.
1 2 3 4 5 6 "Tavalisse- fostamatinib tablet". DailyMed. 10 May 2018. Archived from the original on 28 October 2020. Retrieved 5 May 2020.
1 2 "Tavlesse EPAR". European Medicines Agency (EMA). 12 November 2019. Archived from the original on 25 August 2021. Retrieved 2020-03-26. This article incorporates text from this source, which is in the public domain.
↑ "Fostamatinib Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 17 April 2021. Retrieved 13 December 2021.
↑ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1081. ISBN 978-0857114105.
↑ "Tavalisse Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 17 April 2021. Retrieved 13 December 2021.

[Drugs.com_pregnancy-1] "Fostamatinib (Tavalisse) Use During Pregnancy". Drugs.com. 22 October 2018. Archived from the original on 26 March 2020. Retrieved 5 May 2020.

[PI2021-2] 1 2 3 4 5 6 "Tavalisse- fostamatinib tablet". DailyMed. 10 May 2018. Archived from the original on 28 October 2020. Retrieved 5 May 2020.

[EPAR2021-3] 1 2 "Tavlesse EPAR". European Medicines Agency (EMA). 12 November 2019. Archived from the original on 25 August 2021. Retrieved 2020-03-26. This article incorporates text from this source, which is in the public domain.

[AHFS2021-4] "Fostamatinib Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 17 April 2021. Retrieved 13 December 2021.

[BNF81-5] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1081. ISBN 978-0857114105.

[6] "Tavalisse Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 17 April 2021. Retrieved 13 December 2021.

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