ଫାମସାଇକ୍ଲୋଭିର

ଫାମସାଇକ୍ଲୋଭିର
Clinical data
Pronunciation	/ˌfæmˈsaɪkloʊˌvɪər/
Trade names	Famvir, others
AHFS/Drugs.com	monograph
MedlinePlus	a694038
Pregnancy; category	AU: B1 ; US: B (No risk in non-human studies) ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S3 (Pharmacist only) ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	75–77%
Protein binding	20–25%
Metabolism	Liver, circulation, intestinal wall (to penciclovir)
Elimination half-life	2–2.3 hours
Excretion	Kidney, faecal
Identifiers
	IUPAC name 2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate;
ECHA InfoCard	100.158.713
Chemical and physical data
Formula	C14H19N5O4
Molar mass	୩୨୧.୩୪ g·mol−1
3D model (JSmol)	Interactive image;
Melting point	103 °C (217 °F)
	SMILES O=C(OCC(COC(=O)C)CCn1c2nc(ncc2nc1)N)C;
	InChI InChI=1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18) ; Key:GGXKWVWZWMLJEH-UHFFFAOYSA-N ;
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ଫାମସାଇକ୍ଲୋଭିର (ଇଂରାଜୀ ଭାଷାରେ Famciclovir), ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ଫାମ‌ଭିର (Famvir), ହେଉଛି ଏକ ଔଷଧ ଯାହା ହର୍ପିସ୍ ଜୋଷ୍ଟର ଏବଂ ହର୍ପିସ୍ ସିମ୍ପ୍ଲେକ୍ସ ରୋଗମାନଙ୍କରେ ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୨] ଏହା ଜେନିଟାଲ ହର୍ପିସ ଏବଂ ହର୍ପିସ ଲେବିଆଲିସ ରୋଗ ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ଏବଂ ସକ୍ରିୟ ରୋଗର ଚିକିତ୍ସା ତଥା ବିସ୍ତାରକୁ ରୋକିବା ପାଇଁ ବ୍ୟବହୃତ ହୋଇପାରେ ।^[୩] ଏହା ପାଟିରେ ଦିଆଯାଏ | ^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡବିନ୍ଧା, ଅଇ, ଏବଂ ତରଳ ଝାଡ଼ା ହୋଇପାରେ ।^[୩] ବୃକ୍‌କ ସମସ୍ୟା ଥିଲେ ସ୍ୱଳ୍ପ ମାତ୍ରା ବ୍ୟବହାର କରାଯାଇପାରେ ।^[୩] ଗର୍ଭାବସ୍ଥାରେ କ୍ଷତିର କୌଣସି ପ୍ରମାଣ ନଥିବାବେଳେ ଏହାର ବ୍ୟବହାରର ଅଧ୍ୟୟନ ଭଲ ଭାବରେ କରାଯାଇ ନାହିଁ ।^[୪] ଏହା ପେନସାଇକ୍ଲୋଭିରର ଏକ ପ୍ରୋଡ୍ରଗ ।^[୨] ଏହା ଏକ ଗୁଆନୋସିନ୍ ଆନାଲଗ ସୃଷ୍ଟି କରେ ଯାହା ଫଳରେ ଡିଏନଏ ପଲିମରେଜ ଅବରୋଧ ହୋଇଥାଏ ^[୨]

ଫାମସାଇକ୍ଲୋଭିର ୧୯୮୩ ମସିହାରେ ପ୍ୟାଟେଣ୍ଟ ହୋଇଥିଲା ଏବଂ ୧୯୯୪ରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୫] ^[୬] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୭] ଯୁକ୍ତରାଜ୍ୟରେ ୫୦୦ ମିଗ୍ରା ବିଶିଷ୍ଟ ୧୪ଟି ବଟିକାର ମୂଲ୍ୟ ୨୦୨୧ ସୁଦ୍ଧା ୨୮୦ ପାଉଣ୍ଡ ଥିଲା ।^[୭] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ମୂଲ୍ୟ ପ୍ରାୟ ୧୬ ଡଲାର ଅଟେ ।^[୮]

ଆଧାର

↑ "Famciclovir". Merriam-Webster Dictionary.
1 2 3 "Famciclovir". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 15 May 2021. Retrieved 10 December 2021.
1 2 3 4 "Famciclovir Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 16 November 2021. Retrieved 10 December 2021.
↑ "Famciclovir (Famvir) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 November 2020. Retrieved 10 December 2021.
↑ Long SS, Pickering LK, Prober CG (2012). Principles and Practice of Pediatric Infectious Disease. Elsevier Health Sciences. p. 1502. ISBN 978-1437727029. Archived from the original on 2019-12-29. Retrieved 2020-12-06.
↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 504. ISBN 9783527607495. Archived from the original on 2016-12-20. Retrieved 2020-12-06.
1 2 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 675. ISBN 978-0857114105.
↑ "Famciclovir Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 10 December 2021.

[1] "Famciclovir". Merriam-Webster Dictionary.

[Liv2021-2] 1 2 3 "Famciclovir". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 15 May 2021. Retrieved 10 December 2021.

[AHFS2021-3] 1 2 3 4 "Famciclovir Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 16 November 2021. Retrieved 10 December 2021.

[4] "Famciclovir (Famvir) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 November 2020. Retrieved 10 December 2021.

[5] Long SS, Pickering LK, Prober CG (2012). Principles and Practice of Pediatric Infectious Disease. Elsevier Health Sciences. p. 1502. ISBN 978-1437727029. Archived from the original on 2019-12-29. Retrieved 2020-12-06.

[Fis2006-6] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 504. ISBN 9783527607495. Archived from the original on 2016-12-20. Retrieved 2020-12-06.

[BNF81-7] 1 2 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 675. ISBN 978-0857114105.

[8] "Famciclovir Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 10 December 2021.

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