ସେଫପୋଡୋକ୍ସିମ

ସେଫପୋଡୋକ୍ସିମ
Clinical data
Trade names	Vantin, others
Synonyms	Cephpodoxime, cefpodoxime proxetil
AHFS/Drugs.com	monograph
MedlinePlus	a698024
Pregnancy; category	AU: B1 ; US: B (No risk in non-human studies) ;
Routes of; administration	By mouth
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Bioavailability	50%
Protein binding	21% to 29%
Metabolism	Negligible. Cefpodoxime proxetil is metabolized to cefpodoxime by the liver
Elimination half-life	2 hours
Excretion	Kidney, unchanged
Identifiers
	IUPAC name (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;
ECHA InfoCard	100.210.871
Chemical and physical data
Formula	C15H17N5O6S2
Molar mass	୪୨୭.୪୫ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C(=N\OC)/c3nc(sc3)N)COC)C(=O)O;
	InChI InChI=1S/C15H17N5O6S2/c1-25-3-6-4-27-13-9(12(22)20(13)10(6)14(23)24)18-11(21)8(19-26-2)7-5-28-15(16)17-7/h5,9,13H,3-4H2,1-2H3,(H2,16,17)(H,18,21)(H,23,24)/b19-8-/t9-,13-/m1/s1 ; Key:WYUSVOMTXWRGEK-HBWVYFAYSA-N ;
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ସେଫପୋଡୋକ୍ସିମ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ଭାଣ୍ଟିନ୍, ହେଉଛି ଏକ ଆଣ୍ଟିବାୟୋଟିକ ଯାହା ମଧ୍ୟକର୍ଣ୍ଣ ପ୍ରଦାହ, ଷ୍ଟ୍ରେପ୍ ଗଳା, ସାଇନୁସାଇଟିସ୍, ମୂତ୍ରନଳୀ ସଂକ୍ରମଣ ଏବଂ ଗନରିଆ ରୋଗମାନଙ୍କର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୧] ଏହା ପାଟିରେ ଦିଆଯାଏ । ^[୧]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତରଳ ଝାଡ଼ା, ବାନ୍ତି, ଯୋନୀପଥ ଇଷ୍ଟ ସଂକ୍ରମଣ, ପେଟ ଯନ୍ତ୍ରଣା ଏବଂ ମୁଣ୍ଡବିନ୍ଧା ହୋଇପାରେ । ^[୨] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା ଏବଂ କ୍ଲୋଷ୍ଟ୍ରିଡିଓଡେସ୍ ଡିଫାଇସିଲ୍ ସଂକ୍ରମଣ ହୋଇପାରେ । ^[୧] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ସହିତ କୌଣସି କ୍ଷତି ହେବାର ପ୍ରମାଣ ନଥିବାବେଳେ, ଏହାର ବ୍ୟବହାରର ଭଲରୂପେ ଅଧ୍ୟୟନ କରାଯାଇ ନାହିଁ । ^[୩] ଏହା ଏକ ତୃତୀୟ ପିଢ଼ୀର ସେଫାଲୋସ୍ପୋରିନ୍ ଏବଂ ଜୀବାଣୁର କୋଷ କାନ୍ଥରେ ହସ୍ତକ୍ଷେପ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ । ^[୪]

୧୯୮୦ ମସିହାରେ ସେଫପୋଡୋକ୍ସିମ ପେଟେଣ୍ଟ୍ ହୋଇଥିଲା ଏବଂ ୧୯୮୯ରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ^[୫] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ । ^[୧] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୦ ମିଗ୍ରାର ୨୦ଟି ବଟିକାର ମୂଲ୍ୟ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରାୟ ୩୬ ଡଲାର ଅଟେ। ^[୬]

ଆଧାର

1 2 3 4 "Cefpodoxime Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 January 2021. Retrieved 30 December 2021.
↑ "DailyMed - CEFPODOXIME PROXETIL tablet, film coated". dailymed.nlm.nih.gov. Archived from the original on 28 December 2021. Retrieved 30 December 2021.
↑ "Cefpodoxime (Vantin) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 November 2020. Retrieved 30 December 2021.
↑ Beauduy, Camille E.; Winston, Lisa G. (2020). "43. Beta-lactam and other cell wall - & membrane - active antibiotics". In Katzung, Bertram G.; Trevor, Anthony J. (eds.). Basic and Clinical Pharmacology (in ଇଂରାଜୀ) (15th ed.). New York: McGraw-Hill. p. 832. ISBN 978-1-260-45231-0. Archived from the original on 2021-10-10. Retrieved 2021-11-30.
↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 495. ISBN 9783527607495. Archived from the original on 2016-12-20. Retrieved 2021-06-11.
↑ "Cefpodoxime Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 9 November 2016. Retrieved 30 December 2021.

[AHFS2021-1] 1 2 3 4 "Cefpodoxime Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 January 2021. Retrieved 30 December 2021.

[PI2021-2] "DailyMed - CEFPODOXIME PROXETIL tablet, film coated". dailymed.nlm.nih.gov. Archived from the original on 28 December 2021. Retrieved 30 December 2021.

[3] "Cefpodoxime (Vantin) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 November 2020. Retrieved 30 December 2021.

[Katzung2021-4] Beauduy, Camille E.; Winston, Lisa G. (2020). "43. Beta-lactam and other cell wall - & membrane - active antibiotics". In Katzung, Bertram G.; Trevor, Anthony J. (eds.). Basic and Clinical Pharmacology (in ଇଂରାଜୀ) (15th ed.). New York: McGraw-Hill. p. 832. ISBN 978-1-260-45231-0. Archived from the original on 2021-10-10. Retrieved 2021-11-30.

[Fis2006-5] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 495. ISBN 9783527607495. Archived from the original on 2016-12-20. Retrieved 2021-06-11.

[6] "Cefpodoxime Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 9 November 2016. Retrieved 30 December 2021.

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