କାରିପ୍ରାଜାଇନ

କାରିପ୍ରାଜାଇନ
Clinical data
Pronunciation	/kəˌripˈrəziːn/
Trade names	Vraylar (US), Reagila (EU)
Synonyms	RGH-188
AHFS/Drugs.com	monograph
Pregnancy; category	AU: D ;
Routes of; administration	By mouth (capsules)
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Bioavailability	High
Protein binding	91–97%
Metabolism	Liver via CYP3A4 and to a lesser extent CYP2D6
Metabolites	Desmethylcariprazine
Elimination half-life	2–5 days (2–3 wks for active metabolite, desmethylcariprazine)
Excretion	Urine (21%), bile
Identifiers
	IUPAC name N'-[trans-4-[2-[4-(2,3-Dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-N,N-dimethylurea;
Chemical and physical data
Formula	C21H32Cl2N4O
Molar mass	୪୨୭.୪୧ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc(Cl)c2Cl)CC1;
	InChI InChI=1S/C21H32Cl2N4O/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23/h3-5,16-17H,6-15H2,1-2H3,(H,24,28)/t16-,17- ; Key:KPWSJANDNDDRMB-QAQDUYKDSA-N ;

୍ଟ

କାରିପ୍ରାଜାଇନ, ବିକ୍ରୟ ନାମ ବ୍ରାଏଲ୍, ଏକ ଆଟିପିକାଲ ଆଣ୍ଟିସାଇକୋଟିକ ଔଷଧ ଯାହା ସିଜୋଫ୍ରେନିଆ ଏବଂ ବାଇ ପୋଲାର ଡିଜଅର୍ଡର ରୋଗମାନଙ୍କର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୪] ଏହା ପାଟିରେ ଦିଆଯାଏ । ^[୪] ୱେଲ୍ସରେ ଏହାର ବ୍ୟବହାର ସୁପାରିଶ କରାଯାଏ ନାହିଁ । ^[୫]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଗତିବିଧି ବ୍ୟାଘାତ, ବୁକୁଜ୍ୱାଳା, ନିଦ୍ରାଳୁ ଭାବ ଏବଂ ଅସ୍ଥିରତା ହୋଇପାରେ । ^[୪] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନ୍ୟୁରୋଲେପ୍ଟିକ୍ ମାଲିଗନାଣ୍ଟ ସିଣ୍ଡ୍ରୋମ, ଟାର୍ଡିଭ୍ ଡିସକାଇନେସିଆ, ମଧୁମେହ, ଓଜନ ବୃଦ୍ଧି, ସ୍ୱଳ୍ପ ଶ୍ୱେତ ରକ୍ତ କଣିକା, ଠିଆ ହେବା ସମୟରେ ନିମ୍ନ ରକ୍ତଚାପ ଏବଂ ବାତ ହୋଇପାରେ। ^[୪] ଡିମେନ୍ସିଆ ଥିବା ବୟସ୍କ ବ୍ୟକ୍ତିଙ୍କ ମୃତ୍ୟୁ ମୃତ୍ୟୁ ଆଶଙ୍କା ଅଧିକ ଥାଏ। ^[୪] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ। ^[୬] ଏହା ମୁଖ୍ୟତଃ ଡୋପାମାଇନ୍ ଏବଂ ସେରୋଟୋନିନ୍ ରିସେପ୍ଟର ଉପରେ କାର୍ଯ୍ୟ କରିଥାଏ | ^[୭]

୨୦୧୫ରେ ଆମେରିକାରେ ଏବଂ ୨୦୧୭ରେ ୟୁରୋପରେ ଚିକିତ୍ସା ପାଇଁ କାରିପ୍ରାଜାଇନ୍ ବ୍ୟବହାର ଅନୁମୋଦିତ ହୋଇଥି ଲା। ^[୭]^[୪] ଯୁକ୍ତରାଜ୍ୟରେ ଏହାର ୪ ସପ୍ତାହ ଚିକିତ୍ସାର ଖର୍ଚ୍ଚ ୨୦୨୧ରେ ୮୦ ପାଉଣ୍ଡ ଥିଲା ।^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହାର ମୂଲ୍ୟ ପ୍ରାୟ ୧,୨୫୦ ଡଲାର । ^[୮]

ଆଧାର

↑ "Reagila 1.5 mg hard capsules - Summary of Product Characteristics (SmPC)". (emc). 9 August 2018. Archived from the original on 21 October 2020. Retrieved 20 October 2020.
↑ "Vraylar- cariprazine capsule, gelatin coated Vraylar- cariprazine kit". DailyMed. 18 May 2019. Archived from the original on 24 October 2020. Retrieved 20 October 2020.
↑ "Reagila EPAR". European Medicines Agency (EMA). Archived from the original on 24 October 2020. Retrieved 20 October 2020.
1 2 3 4 5 6 "DailyMed - VRAYLAR- cariprazine capsule, gelatin coated". dailymed.nlm.nih.gov. Archived from the original on 11 January 2022. Retrieved 30 December 2021.
1 2 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 416. ISBN 978-0857114105.
↑ "Cariprazine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 21 January 2021. Retrieved 30 December 2021.
1 2 "Reagila". Archived from the original on 24 October 2020. Retrieved 30 December 2021.
↑ "Cariprazine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 30 December 2021.

[1] "Reagila 1.5 mg hard capsules - Summary of Product Characteristics (SmPC)". (emc). 9 August 2018. Archived from the original on 21 October 2020. Retrieved 20 October 2020.

[Vraylar_PI-2] "Vraylar- cariprazine capsule, gelatin coated Vraylar- cariprazine kit". DailyMed. 18 May 2019. Archived from the original on 24 October 2020. Retrieved 20 October 2020.

[Reagila_EPAR-3] "Reagila EPAR". European Medicines Agency (EMA). Archived from the original on 24 October 2020. Retrieved 20 October 2020.

[PI2021-4] 1 2 3 4 5 6 "DailyMed - VRAYLAR- cariprazine capsule, gelatin coated". dailymed.nlm.nih.gov. Archived from the original on 11 January 2022. Retrieved 30 December 2021.

[BNF81-5] 1 2 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 416. ISBN 978-0857114105.

[AHFS2021-6] "Cariprazine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 21 January 2021. Retrieved 30 December 2021.

[EPAR2021-7] 1 2 "Reagila". Archived from the original on 24 October 2020. Retrieved 30 December 2021.

[8] "Cariprazine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 30 December 2021.

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