ବ୍ରିଞ୍ଜୋଲାମାଇଡ

ବ୍ରିଞ୍ଜୋଲାମାଇଡ
Clinical data
Pronunciation	brin ZOH la mide
Trade names	Azopt, Befardin, others
AHFS/Drugs.com	monograph
MedlinePlus	a601233
data	EU EMA: yes; US DailyMed: Brinzolamide;
Pregnancy; category	AU: B3 ; ;
Routes of; administration	Eye drop
Legal status
Legal status	AU: S4 (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Bioavailability	Absorbed systemically, but below detectable levels (less than 10 ng/mL)
Protein binding	~60%
Elimination half-life	111 days
Excretion	Kidney (60%)
Identifiers
	IUPAC name (5R)-5-ethylamino-3-(3-methoxypropyl)-; 2,2-dioxo-2λ6,9-dithia-; 3-azabicyclo[4.3.0]nona-7,10-diene-; 8-sulfonamide;
ECHA InfoCard	100.149.376
Chemical and physical data
Formula	C12H21N3O5S3
Molar mass	୩୮୩.୫0 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=S(=O)(c1sc2c(c1)[C@@H](NCC)CN(CCCOC)S2(=O)=O)N;
	InChI InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1 ; Key:HCRKCZRJWPKOAR-JTQLQIEISA-N ;
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ବ୍ରିଞ୍ଜୋଲାମାଇଡ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବିକ୍ରୟ ନାମ ଆଜୋପ୍ଟ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଗ୍ଲୁକୋମା, ବିଶେଷ ଭାବରେ ଓପନ୍ ଆଙ୍ଗଲ୍ ଗ୍ଲୁକୋମା ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ । ^[୨] ଏହା ବିଟା ବ୍ଲକର କିମ୍ବା ପ୍ରୋଷ୍ଟାଗ୍ଲାଣ୍ଡିନ ସହିତ ଏକତ୍ର ବ୍ୟବହୃତ ହୁଏ । ^[୩] ଏହା ଆଖି ବୁନ୍ଦା ଭାବରେ ବ୍ୟବହୃତ ହୁଏ ।^[୪]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ପାଟିରେ ଏକ ତିକ୍ତ ସ୍ୱାଦ ଏବଂ ଅସ୍ଥାୟୀ ଅସ୍ପଷ୍ଟ ଦର୍ଶନ ହୋଇପାରେ । ^[୩] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ । ^[୫] ଏହା ଏକ କାର୍ବୋନିକ ଆନହାଇଡ୍ରେଜ ଇନହିବିଟର ଯାହା ଆକ୍ୱିଅସ ହ୍ୟୁମର ଉତ୍ପାଦନକୁ ହ୍ରାସ କରିଥାଏ । ^[୨] ^[୬]

୧୯୯୮ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏବଂ ୨୦୦୦ରେ ୟୁରୋପରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ବ୍ରିନଜୋଲାମାଇଡ୍ ଅନୁମୋଦିତ ହୋଇଥିଲା। ^[୨] ^[୩] ଜେନେରିକ୍ ସଂସ୍କରଣ ୨୦୨୦ ମସିହାରେ ଜେନେରିକ ସଂସ୍କରଣ ଅନୁମୋଦିତ ହୋଇଥିଲା। ^[୭] ଯୁକ୍ତରାଜ୍ୟରେ ଏହାର ୨୦୨୧ ସୁଦ୍ଧା ମୂଲ୍ୟ ୩ ପାଉଣ୍ଡ ଥିଲା । ^[୮] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣ ମୂଲ୍ୟ ପ୍ରାୟ ୪୭ ଡଲାର ଅଟେ । ^[୯]

ଆଧାର

↑ "Brinzolamide ophthalmic (Azopt) Use During Pregnancy". Drugs.com. 16 May 2019. Archived from the original on 28 November 2020. Retrieved 17 August 2020.
↑ ^୨.୦ ^୨.୧ ^୨.୨ "Brinzolamide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 January 2021. Retrieved 11 January 2022.
↑ ^୩.୦ ^୩.୧ ^୩.୨ "Azopt". Archived from the original on 29 April 2021. Retrieved 11 January 2022.
↑ "Brinzolamide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 January 2021. Retrieved 11 January 2022.
↑ "Brinzolamide". Archived from the original on 19 April 2021. Retrieved 11 January 2022.
↑ "Azopt". Archived from the original on 29 April 2021. Retrieved 11 January 2022.
↑ Research, Center for Drug Evaluation and (23 February 2021). "2020 First Generic Drug Approvals". FDA (in ଇଂରାଜୀ). Archived from the original on 26 September 2021. Retrieved 11 January 2022.
↑ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1226. ISBN 978-0857114105.
↑ "Brinzolamide Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 2 October 2016. Retrieved 11 January 2022.

[Drugs.com_pregnancy-1] "Brinzolamide ophthalmic (Azopt) Use During Pregnancy". Drugs.com. 16 May 2019. Archived from the original on 28 November 2020. Retrieved 17 August 2020.

[AHFS2022-2] ୨.୦ ^୨.୧ ^୨.୨ "Brinzolamide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 January 2021. Retrieved 11 January 2022.

[EPAR2022-3] ୩.୦ ^୩.୧ ^୩.୨ "Azopt". Archived from the original on 29 April 2021. Retrieved 11 January 2022.

[autogen3-4] "Brinzolamide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 January 2021. Retrieved 11 January 2022.

[PI2022-5] "Brinzolamide". Archived from the original on 19 April 2021. Retrieved 11 January 2022.

[autogen4-6] "Azopt". Archived from the original on 29 April 2021. Retrieved 11 January 2022.

[7] Research, Center for Drug Evaluation and (23 February 2021). "2020 First Generic Drug Approvals". FDA (in ଇଂରାଜୀ). Archived from the original on 26 September 2021. Retrieved 11 January 2022.

[BNF81-8] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1226. ISBN 978-0857114105.

[9] "Brinzolamide Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 2 October 2016. Retrieved 11 January 2022.

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