ବୋସେଣ୍ଟାନ

ବୋସେଣ୍ଟାନ
Clinical data
Trade names	Tracleer, Stayveer
AHFS/Drugs.com	monograph
MedlinePlus	a605001
data	EU EMA: yes; US DailyMed: Bosentan;
Pregnancy; category	AU: X (High risk) ; US: X (Contraindicated) ; X;
Routes of; administration	By mouth
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	50%
Protein binding	>98%
Metabolism	Liver
Elimination half-life	5 hours
Identifiers
	IUPAC name 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzene-1-sulfonamide;
ECHA InfoCard	100.171.206
Chemical and physical data
Formula	C27H29N5O6S
Molar mass	୫୫୧.୬୨ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc2c(c(nc(n2)c3ncccn3)OCCO)Oc4ccccc4OC;
	InChI InChI=1S/C27H29N5O6S/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24/h5-15,33H,16-17H2,1-4H3,(H,30,31,32) ; Key:GJPICJJJRGTNOD-UHFFFAOYSA-N ;
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ବୋସେଣ୍ଟାନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ବେପାର ନାମ ଟ୍ରା କଲିର, ଏକ ଔଷଧ ଯାହା ଫୁସଫୁସ ଧମନୀ ଉଚ୍ଚ ରକ୍ତଚାପ (PAH) ଏବଂ ସିଷ୍ଟମିକ୍ ସ୍କ୍ଲେରୋସିସ୍ ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୪] ^[୫] ଏହା ପାଟିରେ ଦିଆଯାଏ । ^[୬] ଏହା ୨ ବର୍ଷରୁ ଅଧିକ ବୟସରେ ବ୍ୟବହୃତ ହୋଇପାରେ । ^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଶ୍ୱାସକ୍ରିୟା ସଂକ୍ରମଣ, ନିମ୍ନ ଲାଲ ରକ୍ତ କଣିକା ସ୍ତର ଏବଂ ଜ୍ୱର ଅନ୍ତର୍ଭୁକ୍ତ । ^[୪] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଫୁଲା, ଯକୃତ ସମସ୍ୟା ଏବଂ ଫୁସଫୁସ ରେନୋ-ଆକ୍ଟିଭ ରୋଗ ହୋଇପାରେ । ^[୩] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ । ^[୩] ଏହା ଏକ ଏଣ୍ଡୋଥେଲିନ ରିସେପ୍ଟର ଆଣ୍ଟାଗୋନିଷ୍ଟ । ^[୩]

୨୦୦୧ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏବଂ ୨୦୨୨ରେ ୟୁରୋପରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ବୋସେଣ୍ଟାନ ଅନୁମୋଦିତ ହୋଇଥିଲା। ^[୪] ^[୭] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ଅଟେ। ^[୫] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ମସିହାରୁ ୪ ସପ୍ତାହ ଚିକିତ୍ସା ଖର୍ଚ୍ଚ ପ୍ରାୟ £ ୧୧୦ ଅଟେ। ^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ମୂଲ୍ୟ ପ୍ରାୟ ୧୧୦୦ ଡଲାର ଅଟେ। ^[୮]

ଆଧାର

↑ "Tracleer EPAR". European Medicines Agency (EMA). Archived from the original on 5 November 2021. Retrieved 16 October 2020.
↑ "Tracleer (bosentan) 62.5 mg and 125mg film-coated tablets". UK Electronic Medicines Compendium. May 2017. Archived from the original on 27 July 2020. Retrieved 6 August 2017.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ "Tracleer- bosentan tablet, film coated Tracleer- bosentan tablet, soluble". DailyMed. 15 June 2020. Archived from the original on 12 May 2021. Retrieved 15 October 2020.
↑ ^୪.୦ ^୪.୧ ^୪.୨ "Tracleer- bosentan tablet, film coated Tracleer- bosentan tablet, soluble". DailyMed. 15 June 2020. Archived from the original on 12 May 2021. Retrieved 15 October 2020.
↑ ^୫.୦ ^୫.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 198. ISBN 978-0857114105.
↑ ^୬.୦ ^୬.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 198. ISBN 978-0857114105.
↑ "Tracleer EPAR". European Medicines Agency (EMA). Archived from the original on 5 November 2021. Retrieved 16 October 2020.
↑ "Bosentan Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 11 January 2022.

[EPAR2022-1] "Tracleer EPAR". European Medicines Agency (EMA). Archived from the original on 5 November 2021. Retrieved 16 October 2020.

[UKlabel2017-2] "Tracleer (bosentan) 62.5 mg and 125mg film-coated tablets". UK Electronic Medicines Compendium. May 2017. Archived from the original on 27 July 2020. Retrieved 6 August 2017.

[autogen1-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ "Tracleer- bosentan tablet, film coated Tracleer- bosentan tablet, soluble". DailyMed. 15 June 2020. Archived from the original on 12 May 2021. Retrieved 15 October 2020.

[PI2022-4] ୪.୦ ^୪.୧ ^୪.୨ "Tracleer- bosentan tablet, film coated Tracleer- bosentan tablet, soluble". DailyMed. 15 June 2020. Archived from the original on 12 May 2021. Retrieved 15 October 2020.

[BNF81-5] ୫.୦ ^୫.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 198. ISBN 978-0857114105.

[autogen2-6] ୬.୦ ^୬.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 198. ISBN 978-0857114105.

[autogen4-7] "Tracleer EPAR". European Medicines Agency (EMA). Archived from the original on 5 November 2021. Retrieved 16 October 2020.

[8] "Bosentan Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 11 January 2022.

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