ଆଜାସିଟିଡାଇନ

ଆଜାସିଟିଡାଇନ
Clinical data
Pronunciation	ay" za sye' ti deen
Trade names	Vidaza, Azadine, Onureg
Synonyms	5-Azacytidine, azacytidine, ladakamycin, 4-Amino-1-β-D-ribofuranosyl-s-triazin-2(1H)-one, U-18496, CC-486
AHFS/Drugs.com	monograph
MedlinePlus	a607068
data	EU EMA: yes; US DailyMed: Azacitidine;
Pregnancy; category	AU: X (High risk) ;
Routes of; administration	Subcutaneous injection, intravenous, by mouth
Legal status
Legal status	AU: S4 (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Elimination half-life	4 hr.
Identifiers
	IUPAC name 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one;
ECHA InfoCard	100.005.711
Chemical and physical data
Formula	C8H12N4O5
Molar mass	୨୪୪.୨୧ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1/N=C(\N=C/N1[C@@H]2O[C@@H]([C@@H](O)[C@H]2O)CO)N;
	InChI InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1 ; Key:NMUSYJAQQFHJEW-KVTDHHQDSA-N ;
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ଆଜାସିଟିଡାଇନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ଭିଡାଜା, ଏକ ଔଷଧ ଯାହା ମାଇଲୋଡିସପ୍ଲାଷ୍ଟିକ୍ ସିଣ୍ଡ୍ରୋମ, ଆକ୍ୟୁଟ୍ ମାଇଲୋଏଡ୍ ଲ୍ୟୁକେମିଆ (ଏମ୍ଏଲ୍), କ୍ରନିକ୍ ମାୟେଲୋମୋନୋସାଇଟିକ ଲ୍ୟୁକେମିଆର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୫] ^[୬] ଏହା ଏକ ଶିରାରେ କିମ୍ବା ଚର୍ମ ତଳେ ଇଞ୍ଜେକ୍ସନ ଆକାରରେ ଦିଆଯାଏ । ^[୭]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବାନ୍ତି, ନିମ୍ନ ଲୋହିତ ରକ୍ତ କଣିକା, କମ୍ ପ୍ଲାଲେଟ୍, ଜ୍ୱର, ସ୍ୱଳ୍ପ ଶ୍ୱେତ ରକ୍ତ କଣିକା, ତରଳ ଝାଡ଼ା, କମ୍ ପୋଟାସିୟମ୍ ଏବଂ ଘା ’ହୋଇପାରେ । ^[୮] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଯକୃତ ସମସ୍ୟା, ବୃକ୍‌କ ସମସ୍ୟା ଏବଂ ଟ୍ୟୁମର ଲାଇସିସ୍ ସିଣ୍ଡ୍ରୋମ ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ । ^[୮] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ । ^[୮] ଏହା ଏକ ସାଇଟୋସିନ୍ ଆନାଲଗ ଯାହା <a href="./ଡିଏନ୍ଏ ମିଥାଇଲେସନ୍ |" rel="mw:WikiLink" data-linkid="189" data-cx="{&quot;adapted&quot;:false,&quot;sourceTitle&quot;:{&quot;title&quot;:&quot;DNA methylation&quot;,&quot;thumbnail&quot;:{&quot;source&quot;:&quot;https://upload.wikimedia.org/wikipedia/commons/thumb/9/90/DNA_methylation.svg/80px-DNA_methylation.svg.png&quot;,&quot;width&quot;:80,&quot;height&quot;:46},&quot;description&quot;:&quot;Biological{{Dead link|date=October 2023 |bot=InternetArchiveBot |fix-attempted=yes }} process&quot;,&quot;pageprops&quot;:{&quot;wikibase_item&quot;:&quot;Q874745&quot;},&quot;pagelanguage&quot;:&quot;en&quot;},&quot;targetFrom&quot;:&quot;mt&quot;}" class="cx-link" id="mwKA" title="ଡିଏନ୍ଏ ମିଥାଇଲେସନ୍ |">ଡିଏନଏ</a> ମିଥାଇଲେସନ୍ ଅବରୋଧ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ । ^[୫]

୨୦୦୪ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏବଂ ୨୦୦୮ରେ ୟୁରୋପରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଆଜାସିଟିଡାଇନ୍ ଅନୁମୋଦିତ ହୋଇଥିଲା। ^[୮] ^[୯] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ। ^[୬] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ସୁଦ୍ଧା ଏହି ଔଷଧର ମୂଲ୍ୟ ପ୍ରାୟ ୨୨୦ ପାଉଣ୍ଡ ଅଟେ। ^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୮୩ ଡଲାର ଅଟେ। ^[୧୦]

ଆଧାର

↑ "Azacitidine (Vidaza) Use During Pregnancy". Drugs.com. 5 May 2020. Archived from the original on 5 December 2020. Retrieved 12 August 2020.
↑ "Vidaza- azacitidine injection, powder, lyophilized, for solution". DailyMed. 2 March 2020. Archived from the original on 5 November 2021. Retrieved 27 September 2020.
↑ "Onureg EPAR". European Medicines Agency. 20 April 2021. Archived from the original on 6 September 2021. Retrieved 6 September 2021.
↑ Vallerand AH, Deglin JH (2009). Davis's drug guide for nurses. Philadelphia: F.A. Davis Company. pp. 204–206. ISBN 978-0-8036-1912-8.
1 2 "Azacitidine". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 11 December 2021. Retrieved 17 January 2022.
1 2 3 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 950. ISBN 978-0857114105.
↑ "Azacitidine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 5 March 2021. Retrieved 17 January 2022.
1 2 3 4 "DailyMed - VIDAZA- azacitidine injection, powder, lyophilized, for solution". dailymed.nlm.nih.gov. Archived from the original on 5 November 2021. Retrieved 17 January 2022.
↑ "Vidaza". Archived from the original on 29 December 2021. Retrieved 17 January 2022.
↑ "Azacitidine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 17 January 2022.

[Drugs.com_pregnancy-1] "Azacitidine (Vidaza) Use During Pregnancy". Drugs.com. 5 May 2020. Archived from the original on 5 December 2020. Retrieved 12 August 2020.

[Vidaza_FDA_label-2] "Vidaza- azacitidine injection, powder, lyophilized, for solution". DailyMed. 2 March 2020. Archived from the original on 5 November 2021. Retrieved 27 September 2020.

[EPAR2022AML-3] "Onureg EPAR". European Medicines Agency. 20 April 2021. Archived from the original on 6 September 2021. Retrieved 6 September 2021.

[4] Vallerand AH, Deglin JH (2009). Davis's drug guide for nurses. Philadelphia: F.A. Davis Company. pp. 204–206. ISBN 978-0-8036-1912-8.

[Liv2022-5] 1 2 "Azacitidine". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 11 December 2021. Retrieved 17 January 2022.

[BNF81-6] 1 2 3 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 950. ISBN 978-0857114105.

[AHFS2022-7] "Azacitidine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 5 March 2021. Retrieved 17 January 2022.

[PI2022-8] 1 2 3 4 "DailyMed - VIDAZA- azacitidine injection, powder, lyophilized, for solution". dailymed.nlm.nih.gov. Archived from the original on 5 November 2021. Retrieved 17 January 2022.

[EAPR2022-9] "Vidaza". Archived from the original on 29 December 2021. Retrieved 17 January 2022.

[10] "Azacitidine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 17 January 2022.

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