ବେଞ୍ଜୋନାଟେଟ

ବେଞ୍ଜୋନାଟେଟ
Clinical data
Trade names	Tessalon, Zonatuss, others
AHFS/Drugs.com	monograph
MedlinePlus	a682640
data	US DailyMed: Benzonatate;
Routes of; administration	By mouth
ATC code	R05DB01 (WHO) ;
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Elimination half-life	3-8 hours
Identifiers
	IUPAC name 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-yl 4-(butylamino)benzoate;
CAS Number	32760-16-0 ;
PubChem CID	7699;
IUPHAR/BPS	7611;
DrugBank	DB00868 ;
ChemSpider	7413 ;
UNII	5P4DHS6ENR;
KEGG	D00242 ;
ChEBI	CHEBI:3032 ;
ChEMBL	CHEMBL1374379 ;
ECHA InfoCard	100.002.904
Chemical and physical data
Formula	C30H53NO11
Molar mass	୬୦୩.୭୫ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCOC)c1ccc(NCCCC)cc1;
	InChI InChI=1S/C30H53NO11/c1-3-4-9-31-29-7-5-28(6-8-29)30(32)42-27-26-41-25-24-40-23-22-39-21-20-38-19-18-37-17-16-36-15-14-35-13-12-34-11-10-33-2/h5-8,31H,3-4,9-27H2,1-2H3 ; Key:MAFMQEKGGFWBAB-UHFFFAOYSA-N ;
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ବେଞ୍ଜୋନାଟେଟ (ଇଂରାଜୀ ଭାଷାରେ Benzonatate, ଏକ ବ୍ରାଣ୍ଡ ନାମ ଟେସାଲନ/ Tessalon) ଏକ ଔଷଧ ଯାହା କାଶ ଏବଂ ହିକପ ଇତ୍ୟାଦି ଲକ୍ଷଣମାନଙ୍କ ଉପଶମ ନିମନ୍ତେ ଦିଆଯାଏ ।^[୧] ^[୨] ଏହା ପାଟିରେ ଦିଆଯାଏ | ^[୩] ଦଶ ବର୍ଷରୁ କମ୍ ବୟସରେ ବ୍ୟବହାର ନିମନ୍ତେ ସୁପାରିଶ କରାଯାଏ ନାହିଁ | ^[୪] ପ୍ରଭାବ ସାଧାରଣତଃ ୨୦ ମିନିଟ୍ ମଧ୍ୟରେ ଆରମ୍ଭ ହୁଏ ଏବଂ ଆଠ ଘଣ୍ଟା ପର୍ଯ୍ୟନ୍ତ ରହିଥାଏ | ^[୩] ^[୫]

ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିଦ୍ରା, ମୁଣ୍ଡ ବୁଲାଇବା, ମୁଣ୍ଡବିନ୍ଧା, ପେଟ ଖରାପ, ଚର୍ମ ଦାଗ, ହାଲୁସିନେସନ ଏବଂ ଆଲର୍ଜି ହୋଇପାରେ | ^[୩] ଅତ୍ୟଧିକ ମାତ୍ରା ଦେଲେ ବାତ, ଅନିୟମିତ ହୃତ୍ ସ୍ପନ୍ଦନ ଏବଂ ମୃତ୍ୟୁ ହୋଇପାରେ। ^[୬] କ୍ୟାପସୁଲକୁ ଚୋବାଇବା କିମ୍ବା ଶୋଷିବାଦ୍ୱାରା ଲାରିଙ୍ଗୋସ୍ପଜ୍ମ, ବ୍ରୋଙ୍କୋସ୍ପାଜ୍ମ ଏବଂ ରକ୍ତ ସଞ୍ଚାଳନରେ ଅସୁବିଧା ହୋଇପାରେ ।^[୩] ଗର୍ଭାବସ୍ଥାରେ କିମ୍ବା ସ୍ତନ୍ୟପାନ ସମୟରେ ଏହାର ବ୍ୟବହାର ସୁରକ୍ଷିତ କି ନାହିଁ ତାହା ଅସ୍ପଷ୍ଟ ରହିଛି। ^[୭] ଏହା ଫୁସଫୁସର ସ୍ଟ୍ରେଚ ରିସେପ୍ଟର ଗୁଡ଼ିକୁ ନମ୍ବ ବା କାଲୁଆ କରିଦିଏ ଓ ମସ୍ତିଷ୍କର କାଶ ରିଫ୍ଲେକ୍ସ ଦମନ କରିଦିଏ ।^[୩]

ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୧୯୫୮ ମସିହାରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ବେଞ୍ଜୋନାଟେଟ ଅନୁମୋଦିତ ହୋଇଥିଲା। ^[୩] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ। ^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହାର ୧୦୦ ମିଗ୍ରା ମାତ୍ରାର ମୂଲ୍ୟ ୦.୧୨ ଡଲାର ।^[୮] ଏହା ଅନେକ ଦେଶରେ ଉପଲବ୍ଧ ନୁହେଁ | ^[୯] ୨୦୧୭ ମସିହାରେ ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୧୪୮ତମ ସାଧାରଣ ପ୍ରେସକ୍ରିପସନ ଔଷଧ ଥିଲା, ଯେଉଁଥିରେ ଚାରି ନିୟୁତରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ୍ ରହିଥିଲା | ^[୧୦] ^[୧୧]

ଆଧାର

↑ "Benzonatate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 23 March 2019.
↑ Becker, DE (2010). "Nausea, vomiting, and hiccups: a review of mechanisms and treatment". Anesthesia Progress. 57 (4): 150–6, quiz 157. doi:10.2344/0003-3006-57.4.150. PMC 3006663. PMID 21174569.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ "Benzonatate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 23 March 2019.
↑ "Drugs for cough". The Medical Letter on Drugs and Therapeutics. 60 (1562): 206–208. 17 December 2018. PMID 30625123.
↑ "Tessalon - benzonatate capsule". DailyMed. 20 November 2019. Retrieved 21 April 2020.
↑ ^୬.୦ ^୬.୧ "Drugs for cough". The Medical Letter on Drugs and Therapeutics. 60 (1562): 206–208. 17 December 2018. PMID 30625123.
↑ "Benzonatate Use During Pregnancy". Drugs.com. 10 October 2019. Retrieved 20 February 2020.
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
↑ Walsh, T. Declan; Caraceni, Augusto T.; Fainsinger, Robin; Foley, Kathleen M.; Glare, Paul; Goh, Cynthia; Lloyd-Williams, Mari; Olarte, Juan Nunez; Radbruch, Lukas (2008). Palliative Medicine E-Book. Elsevier Health Sciences. p. 751. ISBN 9781437721942.
↑ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
↑ "Benzonatate - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.

[AHFS2019-1] "Benzonatate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 23 March 2019.

[Bec2010-2] Becker, DE (2010). "Nausea, vomiting, and hiccups: a review of mechanisms and treatment". Anesthesia Progress. 57 (4): 150–6, quiz 157. doi:10.2344/0003-3006-57.4.150. PMC 3006663. PMID 21174569.

[autogen1-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ "Benzonatate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 23 March 2019.

[ML2018-4] "Drugs for cough". The Medical Letter on Drugs and Therapeutics. 60 (1562): 206–208. 17 December 2018. PMID 30625123.

[Tessalon_label-5] "Tessalon - benzonatate capsule". DailyMed. 20 November 2019. Retrieved 21 April 2020.

[autogen2-6] ୬.୦ ^୬.୧ "Drugs for cough". The Medical Letter on Drugs and Therapeutics. 60 (1562): 206–208. 17 December 2018. PMID 30625123.

[Preg2020-7] "Benzonatate Use During Pregnancy". Drugs.com. 10 October 2019. Retrieved 20 February 2020.

[NADAC2019-8] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.

[Wal2008-9] Walsh, T. Declan; Caraceni, Augusto T.; Fainsinger, Robin; Foley, Kathleen M.; Glare, Paul; Goh, Cynthia; Lloyd-Williams, Mari; Olarte, Juan Nunez; Radbruch, Lukas (2008). Palliative Medicine E-Book. Elsevier Health Sciences. p. 751. ISBN 9781437721942.

[Clin2020-10] "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.

[Clin2020b-11] "Benzonatate - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.

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