ଆଲଭିମୋପାନ

ଆଲଭିମୋପାନ
Clinical data
Trade names	Entereg
Synonyms	Alvimopan, Entereg
AHFS/Drugs.com	monograph
MedlinePlus	a608051
data	US FDA: Alvimopan;
Pregnancy; category	US: B (No risk in non-human studies) ; ;
Routes of; administration	By mouth
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Bioavailability	6%
Protein binding	80% (parent drug), 94% (metabolite)
Metabolism	Gut microflora-mediated hydrolysis to active metabolite
Elimination half-life	10-17 hours
Excretion	Faeces, urine (35%)
Identifiers
	IUPAC name 2-([(2S)-2-([(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl) -3-phenylpropanoyl]amino)acetic acid;
Chemical and physical data
Formula	C25H32N2O4
Molar mass	୪୨୪.୫୪ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)CNC(=O)[C@@H](Cc1ccccc1)CN3CC[C@@](c2cccc(O)c2)([C@H](C3)C)C;
	InChI InChI=1S/C25H32N2O4/c1-18-16-27(12-11-25(18,2)21-9-6-10-22(28)14-21)17-20(24(31)26-15-23(29)30)13-19-7-4-3-5-8-19/h3-10,14,18,20,28H,11-13,15-17H2,1-2H3,(H,26,31)(H,29,30)/t18-,20-,25+/m0/s1 ; Key:UPNUIXSCZBYVBB-JVFUWBCBSA-N ;
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ଆଲଭିମୋପାନ, ବେପାର ନାମ ଏଣ୍ଟେରେଗ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଆଂଶିକ ଅନ୍ତନଳୀ ରିଜେକସନ ପରେ ସର୍ଜିକାଲ୍ ଆନାଷ୍ଟୋମୋସିସର ଇଲିଅସର ପୁନରୁଦ୍ଧାରକୁ ତ୍ୱରାନ୍ୱିତ କରିବା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୧] ଛୋଟ ଅନ୍ତ୍ର କିମ୍ବା ବଡ଼ ଅନ୍ତ୍ର ଅସ୍ତ୍ରୋପଚାର ପରେ ଏହା ବ୍ୟବହୃତ ହୋଇପାରେ । ^[୨] ଏହା ପାଟିରେ ଦିନିଆଯାଏ । ^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବୁକୁଜ୍ୱାଳା ହୋଇପାରେ । ^[୧] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ହୃଦଘାତ ଏବଂ କମ୍ ପୋଟାସିୟମ୍ ହୋଇପାରେ । ^[୧] ^[୨] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ। ^[୩] ଏହା ଏକ ପ୍ରନ୍ତୀୟ କାର୍ଯ୍ୟକ୍ଷମ μ- ଓପିଓଏଡ୍ ରିସେପ୍ଟର ଆଣ୍ଟାଗୋନିଷ୍ଟ । ^[୨]

2008 ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା। ^[୧] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୧୨ ମିଗ୍ରାର ୧୫ ମାତ୍ରାର ମୂଲ୍ୟ ୨୦୨୨ରେ ୨୯୦୦ ଡଲାର ଅଟେ । ^[୪]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ "DailyMed - ALVIMOPAN capsule". dailymed.nlm.nih.gov. Archived from the original on 19 April 2021. Retrieved 14 January 2022.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ "Alvimopan Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 June 2021. Retrieved 14 January 2022.
↑ "Alvimopan (Entereg) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 3 December 2020. Retrieved 14 January 2022.
↑ "Entereg Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 14 January 2022.

[PI2022-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ "DailyMed - ALVIMOPAN capsule". dailymed.nlm.nih.gov. Archived from the original on 19 April 2021. Retrieved 14 January 2022.

[AHFS2022-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ "Alvimopan Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 June 2021. Retrieved 14 January 2022.

[3] "Alvimopan (Entereg) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 3 December 2020. Retrieved 14 January 2022.

[4] "Entereg Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 14 January 2022.

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