ଆଡେଫୋଭିର

ଆଡେଫୋଭିର
Clinical data
Trade names	Hepsera
Synonyms	Adefovir dipivoxil
AHFS/Drugs.com	monograph
Pregnancy; category	AU: B3 ; US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	59%
Protein binding	<4%
Elimination half-life	7.5 hours
Excretion	Urine
Identifiers
	IUPAC name {[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphonic acid;
ECHA InfoCard	100.106.235
Chemical and physical data
Formula	C8H12N5O4P
Molar mass	୨୭୩.୧୯ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=P(O)(O)COCCn1c2ncnc(c2nc1)N;
	InChI InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16) ; Key:SUPKOOSCJHTBAH-UHFFFAOYSA-N ;
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ଆଡେଫୋଭିର, ଏକ ବେପାର ନାମ ହେପସେରା, ହେଉଛି କ୍ରନିକ ହେପାଟାଇଟିସ୍ ବି ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ଏକ ଔଷଧ । ^[୧] ^[୨] ୧୧ ବର୍ଷରୁ ଅଧିକ ବୟସର ରୋଗୀଙ୍କ ପାଇଁ ଏହା ବ୍ୟବହୃତ ହୋଇପାରେ । ଲାମିଭୁଡାଇନ୍ ଔଷଧକୁ ପ୍ରତିରୋଧ ହେଉଥିବା ଲୋକମାନଙ୍କ ମଧ୍ୟରେ ଏହା ପ୍ରଭାବଶାଳୀ ହୋଇପାରେ । ^[୨] ଏହା ପାଟିରେ ଦିଆଯାଏ । ^[୧]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଦୁର୍ବଳତା, ତରଳ ଝାଡ଼ା, ପେଟରେ ଅସୁବିଧା, ମୁଣ୍ଡବିନ୍ଧା, ବାନ୍ତି, ଏବଂ ବୃକ୍‌କ ସମସ୍ୟା ହୋଇପାରେ । ^[୩] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ହାଡ ଭଙ୍ଗା, ଯକୃତ ସମସ୍ୟା ଏବଂ ଅଗ୍ନାଶୟ ପ୍ରଦାହ ହୋଇପାରେ। ^[୩] ^[୨] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ। ^[୪] ଏହା ଏକ ନ୍ୟୁକ୍ଲିଓଟାଇଡ୍ ଆନାଲଗ ରିଭର୍ସ-ଟ୍ରାନ୍ସକ୍ରିପଟେଜ୍ ଇନହିବିଟର (ntRTI) । ^[୩]

୨୦୦୨ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ର ଏବଂ ୨୦୦୩ରେ ୟୁରୋପରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଆଡେଫୋଭିର ଅନୁମୋଦିତ ହୋଇଥିଲା। ^[୨] ^[୫] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ। ^[୧] ଯୁକ୍ତରାଜ୍ୟରେ ଏକ ମାସର ଔଷଧ ୨୦୨୧ ସୁଦ୍ଧା ମୂଲ୍ୟ ୨୫୦ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହୋଇଥାଏ। ^[୩] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶି ପ୍ରାୟ ୮୦୦ ଡଲାର ଅଟେ। ^[୬]

ଆଧାର[ସମ୍ପାଦନା]

↑ ^୧.୦ ^୧.୧ ^୧.୨ "Adefovir". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 13 January 2022. Retrieved 13 January 2022.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ "Adefovir Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 January 2021. Retrieved 13 January 2022.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 663. ISBN 978-0857114105.
↑ "Adefovir (Hepsera) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 21 October 2020. Retrieved 13 January 2022.
↑ "Hepsera". Archived from the original on 19 April 2021. Retrieved 13 January 2022.
↑ "Adefovir Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 19 August 2016. Retrieved 13 January 2022.

[Liv2022-1] ୧.୦ ^୧.୧ ^୧.୨ "Adefovir". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 13 January 2022. Retrieved 13 January 2022.

[AHFS2022-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ "Adefovir Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 January 2021. Retrieved 13 January 2022.

[BNF81-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 663. ISBN 978-0857114105.

[4] "Adefovir (Hepsera) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 21 October 2020. Retrieved 13 January 2022.

[EPAR2022-5] "Hepsera". Archived from the original on 19 April 2021. Retrieved 13 January 2022.

[6] "Adefovir Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 19 August 2016. Retrieved 13 January 2022.

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